ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS

Mitochondrial dysfunction and the loss of mitophagy, aimed at recycling irreversibly damaged organelles, contribute to the onset of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease affecting spinal cord motor neurons. In this work, we showed that the reduction of mitochondrial...

Descripción completa

Detalles Bibliográficos
Autores principales: Magrì, Andrea, Lipari, Cristiana Lucia Rita, Risiglione, Pierpaolo, Zimbone, Stefania, Guarino, Francesca, Caccamo, Antonella, Messina, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931716/
https://www.ncbi.nlm.nih.gov/pubmed/36792609
http://dx.doi.org/10.1038/s41419-023-05643-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931716/
https://www.ncbi.nlm.nih.gov/pubmed/36792609
http://dx.doi.org/10.1038/s41419-023-05643-0

Ejemplares similares