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ERK1/2-dependent TSPO overactivation associates with the loss of mitophagy and mitochondrial respiration in ALS
Mitochondrial dysfunction and the loss of mitophagy, aimed at recycling irreversibly damaged organelles, contribute to the onset of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease affecting spinal cord motor neurons. In this work, we showed that the reduction of mitochondrial...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931716/ https://www.ncbi.nlm.nih.gov/pubmed/36792609 http://dx.doi.org/10.1038/s41419-023-05643-0 |