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Prognostic evaluation of polygenic risk score underlying pan-cancer analysis: evidence from two large-scale cohorts

BACKGROUND: Polygenic risk score (PRS) has been demonstrated to be effective in identifying individuals at high risk of developing cancer, but its prognostic value remains unclear. METHODS: We constructed site-specific PRSs by aggregating the risk effect of independent variants derived from previous...

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Detalles Bibliográficos
Autores principales:	Xin, Junyi, Jiang, Xia, Li, Huiqin, Chen, Silu, Zhang, Zhengdong, Wang, Meilin, Gu, Dongying, Du, Mulong, Christiani, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9931923/ https://www.ncbi.nlm.nih.gov/pubmed/36739632 http://dx.doi.org/10.1016/j.ebiom.2023.104454

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