Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies

Insulin formulations with diverse oligomerization states are the hallmark of interventions for the treatment of diabetes. Here using single-molecule recordings we firstly reveal that insulin oligomerization can operate via monomeric additions and secondly quantify the existence, abundance and kineti...

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Detalles Bibliográficos
Autores principales: Bohr, Freja, Bohr, Søren S. -R., Mishra, Narendra Kumar, González-Foutel, Nicolás Sebastian, Pinholt, Henrik Dahl, Wu, Shunliang, Nielsen, Emilie Milan, Zhang, Min, Kjaergaard, Magnus, Jensen, Knud J., Hatzakis, Nikos S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932072/
https://www.ncbi.nlm.nih.gov/pubmed/36792809
http://dx.doi.org/10.1038/s42003-022-04386-6

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