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Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament
Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown. We identified OPLL characteristics and determined whether they influence neurological sev...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932080/ https://www.ncbi.nlm.nih.gov/pubmed/36792759 http://dx.doi.org/10.1038/s41598-023-29877-2 |
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author | Okuwaki, Shun Funayama, Toru Koda, Masao Eto, Fumihiko Yamaji, Akihiro Yokogawa, Noriaki Sasagawa, Takeshi Ando, Kei Nakashima, Hiroaki Segi, Naoki Watanabe, Kota Nori, Satoshi Takeda, Kazuki Furuya, Takeo Yunde, Atsushi Nakajima, Hideaki Yamada, Tomohiro Hasegawa, Tomohiko Terashima, Yoshinori Hirota, Ryosuke Suzuki, Hidenori Imajo, Yasuaki Ikegami, Shota Uehara, Masashi Tonomura, Hitoshi Sakata, Munehiro Hashimoto, Ko Onoda, Yoshito Kawaguchi, Kenichi Haruta, Yohei Suzuki, Nobuyuki Kato, Kenji Uei, Hiroshi Sawada, Hirokatsu Nakanishi, Kazuo Misaki, Kosuke Terai, Hidetomi Tamai, Koji Shirasawa, Eiki Inoue, Gen Kakutani, Kenichiro Kakiuchi, Yuji Kiyasu, Katsuhito Tominaga, Hiroyuki Tokumoto, Hiroto Iizuka, Yoichi Takasawa, Eiji Akeda, Koji Takegami, Norihiko Funao, Haruki Oshima, Yasushi Kaito, Takashi Sakai, Daisuke Yoshii, Toshitaka Ohba, Tetsuro Otsuki, Bungo Seki, Shoji Miyazaki, Masashi Ishihara, Masayuki Okada, Seiji Imagama, Shiro Kato, Satoshi |
author_facet | Okuwaki, Shun Funayama, Toru Koda, Masao Eto, Fumihiko Yamaji, Akihiro Yokogawa, Noriaki Sasagawa, Takeshi Ando, Kei Nakashima, Hiroaki Segi, Naoki Watanabe, Kota Nori, Satoshi Takeda, Kazuki Furuya, Takeo Yunde, Atsushi Nakajima, Hideaki Yamada, Tomohiro Hasegawa, Tomohiko Terashima, Yoshinori Hirota, Ryosuke Suzuki, Hidenori Imajo, Yasuaki Ikegami, Shota Uehara, Masashi Tonomura, Hitoshi Sakata, Munehiro Hashimoto, Ko Onoda, Yoshito Kawaguchi, Kenichi Haruta, Yohei Suzuki, Nobuyuki Kato, Kenji Uei, Hiroshi Sawada, Hirokatsu Nakanishi, Kazuo Misaki, Kosuke Terai, Hidetomi Tamai, Koji Shirasawa, Eiki Inoue, Gen Kakutani, Kenichiro Kakiuchi, Yuji Kiyasu, Katsuhito Tominaga, Hiroyuki Tokumoto, Hiroto Iizuka, Yoichi Takasawa, Eiji Akeda, Koji Takegami, Norihiko Funao, Haruki Oshima, Yasushi Kaito, Takashi Sakai, Daisuke Yoshii, Toshitaka Ohba, Tetsuro Otsuki, Bungo Seki, Shoji Miyazaki, Masashi Ishihara, Masayuki Okada, Seiji Imagama, Shiro Kato, Satoshi |
author_sort | Okuwaki, Shun |
collection | PubMed |
description | Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown. We identified OPLL characteristics and determined whether they influence neurological severity and improvement of CSCI in older patients. This multicenter retrospective cohort study identified 1512 patients aged ≥ 65 years diagnosed with CSCI on admission during 2010–2020. We analyzed CSCI etiology in OPLL patients. We performed propensity score-adjusted analyses to compare neurological outcomes between patients with and without OPLL. Cases were matched based on variables influencing neurological prognosis. The primary neurological outcome was rated according to the American Spine Injury Association (ASIA) impairment scale (AIS) and ASIA motor score (AMS). In 332 OPLL patients, the male-to-female ratio was approximately 4:1. Half of all patients displayed low-energy trauma-induced injury and one-third had CSCI without a bony injury. Propensity score matching created 279 pairs. There was no significant difference in the AIS grade and AMS between patients with and without OPLL during hospitalization, 6 months, and 12 months following injury. OPLL patients tended to exhibit worse neurological findings during injury; nevertheless, OPLL was not associated with poor neurological improvement in older CSCI patients. |
format | Online Article Text |
id | pubmed-9932080 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-99320802023-02-17 Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament Okuwaki, Shun Funayama, Toru Koda, Masao Eto, Fumihiko Yamaji, Akihiro Yokogawa, Noriaki Sasagawa, Takeshi Ando, Kei Nakashima, Hiroaki Segi, Naoki Watanabe, Kota Nori, Satoshi Takeda, Kazuki Furuya, Takeo Yunde, Atsushi Nakajima, Hideaki Yamada, Tomohiro Hasegawa, Tomohiko Terashima, Yoshinori Hirota, Ryosuke Suzuki, Hidenori Imajo, Yasuaki Ikegami, Shota Uehara, Masashi Tonomura, Hitoshi Sakata, Munehiro Hashimoto, Ko Onoda, Yoshito Kawaguchi, Kenichi Haruta, Yohei Suzuki, Nobuyuki Kato, Kenji Uei, Hiroshi Sawada, Hirokatsu Nakanishi, Kazuo Misaki, Kosuke Terai, Hidetomi Tamai, Koji Shirasawa, Eiki Inoue, Gen Kakutani, Kenichiro Kakiuchi, Yuji Kiyasu, Katsuhito Tominaga, Hiroyuki Tokumoto, Hiroto Iizuka, Yoichi Takasawa, Eiji Akeda, Koji Takegami, Norihiko Funao, Haruki Oshima, Yasushi Kaito, Takashi Sakai, Daisuke Yoshii, Toshitaka Ohba, Tetsuro Otsuki, Bungo Seki, Shoji Miyazaki, Masashi Ishihara, Masayuki Okada, Seiji Imagama, Shiro Kato, Satoshi Sci Rep Article Although the incidence of cervical spinal cord injury (CSCI) with ossification of the posterior longitudinal ligament (OPLL) has increased in older adults, its etiology and neurological outcomes remain unknown. We identified OPLL characteristics and determined whether they influence neurological severity and improvement of CSCI in older patients. This multicenter retrospective cohort study identified 1512 patients aged ≥ 65 years diagnosed with CSCI on admission during 2010–2020. We analyzed CSCI etiology in OPLL patients. We performed propensity score-adjusted analyses to compare neurological outcomes between patients with and without OPLL. Cases were matched based on variables influencing neurological prognosis. The primary neurological outcome was rated according to the American Spine Injury Association (ASIA) impairment scale (AIS) and ASIA motor score (AMS). In 332 OPLL patients, the male-to-female ratio was approximately 4:1. Half of all patients displayed low-energy trauma-induced injury and one-third had CSCI without a bony injury. Propensity score matching created 279 pairs. There was no significant difference in the AIS grade and AMS between patients with and without OPLL during hospitalization, 6 months, and 12 months following injury. OPLL patients tended to exhibit worse neurological findings during injury; nevertheless, OPLL was not associated with poor neurological improvement in older CSCI patients. Nature Publishing Group UK 2023-02-15 /pmc/articles/PMC9932080/ /pubmed/36792759 http://dx.doi.org/10.1038/s41598-023-29877-2 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Okuwaki, Shun Funayama, Toru Koda, Masao Eto, Fumihiko Yamaji, Akihiro Yokogawa, Noriaki Sasagawa, Takeshi Ando, Kei Nakashima, Hiroaki Segi, Naoki Watanabe, Kota Nori, Satoshi Takeda, Kazuki Furuya, Takeo Yunde, Atsushi Nakajima, Hideaki Yamada, Tomohiro Hasegawa, Tomohiko Terashima, Yoshinori Hirota, Ryosuke Suzuki, Hidenori Imajo, Yasuaki Ikegami, Shota Uehara, Masashi Tonomura, Hitoshi Sakata, Munehiro Hashimoto, Ko Onoda, Yoshito Kawaguchi, Kenichi Haruta, Yohei Suzuki, Nobuyuki Kato, Kenji Uei, Hiroshi Sawada, Hirokatsu Nakanishi, Kazuo Misaki, Kosuke Terai, Hidetomi Tamai, Koji Shirasawa, Eiki Inoue, Gen Kakutani, Kenichiro Kakiuchi, Yuji Kiyasu, Katsuhito Tominaga, Hiroyuki Tokumoto, Hiroto Iizuka, Yoichi Takasawa, Eiji Akeda, Koji Takegami, Norihiko Funao, Haruki Oshima, Yasushi Kaito, Takashi Sakai, Daisuke Yoshii, Toshitaka Ohba, Tetsuro Otsuki, Bungo Seki, Shoji Miyazaki, Masashi Ishihara, Masayuki Okada, Seiji Imagama, Shiro Kato, Satoshi Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament |
title | Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament |
title_full | Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament |
title_fullStr | Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament |
title_full_unstemmed | Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament |
title_short | Characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament |
title_sort | characteristics of the cervical spine and cervical cord injuries in older adults with cervical ossification of the posterior longitudinal ligament |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932080/ https://www.ncbi.nlm.nih.gov/pubmed/36792759 http://dx.doi.org/10.1038/s41598-023-29877-2 |
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