Endoplasmic reticulum protein BIK binds to and inhibits mitochondria-localized antiapoptotic proteins

The proapoptotic BCL-2 homology (BH3)-only endoplasmic reticulum (ER)–resident protein BCL-2 interacting killer (BIK) positively regulates mitochondrial outer membrane permeabilization, the point of no return in apoptosis. It is generally accepted that BIK functions at a distance from mitochondria b...

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Detalles Bibliográficos
Autores principales: Osterlund, Elizabeth J., Hirmiz, Nehad, Nguyen, Dang, Pemberton, James M., Fang, Qiyin, Andrews, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932132/
https://www.ncbi.nlm.nih.gov/pubmed/36603764
http://dx.doi.org/10.1016/j.jbc.2022.102863

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