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Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by defective dopaminergic (DAergic) input to the striatum. Mutations in two genes encoding synaptically enriched clathrin-uncoating factors, synaptojanin 1 (SJ1) and auxilin, have been implicated in atypical Parkinsonism. SJ1 kno...

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Detalles Bibliográficos
Autores principales:	Ng, Xin Yi, Wu, Yumei, Lin, Youneng, Yaqoob, Sidra Mohamed, Greene, Lois E., De Camilli, Pietro, Cao, Mian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932162/ https://www.ncbi.nlm.nih.gov/pubmed/36792618 http://dx.doi.org/10.1038/s41531-023-00465-5

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