Cargando…

NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity

Despite advances in combined photothermal/immunotherapy of tumor, the therapeutic effect has been impaired due to hypoxic microenvironment and inadequate immune activation. Manganese ions directly activated the stimulator of interferon genes (STING) pathway and induced innate antitumor immunity. Her...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Qianzhe, Yang, Mengyu, Sun, Xin, Wang, Qinxin, Yu, Beibei, Gong, Aihua, Zhang, Miaomiao, Du, Fengyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932208/
https://www.ncbi.nlm.nih.gov/pubmed/36816600
http://dx.doi.org/10.1016/j.mtbio.2023.100566
_version_ 1784889401788071936
author Li, Qianzhe
Yang, Mengyu
Sun, Xin
Wang, Qinxin
Yu, Beibei
Gong, Aihua
Zhang, Miaomiao
Du, Fengyi
author_facet Li, Qianzhe
Yang, Mengyu
Sun, Xin
Wang, Qinxin
Yu, Beibei
Gong, Aihua
Zhang, Miaomiao
Du, Fengyi
author_sort Li, Qianzhe
collection PubMed
description Despite advances in combined photothermal/immunotherapy of tumor, the therapeutic effect has been impaired due to hypoxic microenvironment and inadequate immune activation. Manganese ions directly activated the stimulator of interferon genes (STING) pathway and induced innate antitumor immunity. Herein, a near infrared light (NIR)-responsive nanoenzyme (PB–Mn/OVA NE) was constructed by doping manganese into the ovalbumin (OVA)-templated Prussian blue (PB) nanoparticles. The resultant PB-Mn/OVA NEs exhibited favorable catalase activity to produce oxygen, which was conducive to alleviate the tumor hypoxic microenvironment. Under 808 ​nm NIR irradiation, the PB-Mn/OVA NEs with outstanding photothermal conversion efficiency of 30% significantly destroyed tumor cells by inducing immunogenic cell death (ICD). Impressively, the PB-Mn/OVA NEs could activate the cGAS-STING pathway to promote the maturation and the antigen cross-presentation ability of dendritic cells (DCs), which further activated cytotoxic T lymphocytes and memory T lymphocytes. Overall, this work presents a powerful nanoenzyme formula to integrate photothermal ablation and hypoxic reversal for triggering robust innate and adaptive antitumor immune response.
format Online
Article
Text
id pubmed-9932208
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-99322082023-02-17 NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity Li, Qianzhe Yang, Mengyu Sun, Xin Wang, Qinxin Yu, Beibei Gong, Aihua Zhang, Miaomiao Du, Fengyi Mater Today Bio Full Length Article Despite advances in combined photothermal/immunotherapy of tumor, the therapeutic effect has been impaired due to hypoxic microenvironment and inadequate immune activation. Manganese ions directly activated the stimulator of interferon genes (STING) pathway and induced innate antitumor immunity. Herein, a near infrared light (NIR)-responsive nanoenzyme (PB–Mn/OVA NE) was constructed by doping manganese into the ovalbumin (OVA)-templated Prussian blue (PB) nanoparticles. The resultant PB-Mn/OVA NEs exhibited favorable catalase activity to produce oxygen, which was conducive to alleviate the tumor hypoxic microenvironment. Under 808 ​nm NIR irradiation, the PB-Mn/OVA NEs with outstanding photothermal conversion efficiency of 30% significantly destroyed tumor cells by inducing immunogenic cell death (ICD). Impressively, the PB-Mn/OVA NEs could activate the cGAS-STING pathway to promote the maturation and the antigen cross-presentation ability of dendritic cells (DCs), which further activated cytotoxic T lymphocytes and memory T lymphocytes. Overall, this work presents a powerful nanoenzyme formula to integrate photothermal ablation and hypoxic reversal for triggering robust innate and adaptive antitumor immune response. Elsevier 2023-01-29 /pmc/articles/PMC9932208/ /pubmed/36816600 http://dx.doi.org/10.1016/j.mtbio.2023.100566 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Full Length Article
Li, Qianzhe
Yang, Mengyu
Sun, Xin
Wang, Qinxin
Yu, Beibei
Gong, Aihua
Zhang, Miaomiao
Du, Fengyi
NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity
title NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity
title_full NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity
title_fullStr NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity
title_full_unstemmed NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity
title_short NIR responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the STING-dependent innate antitumor immunity
title_sort nir responsive nanoenzymes via photothermal ablation and hypoxia reversal to potentiate the sting-dependent innate antitumor immunity
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932208/
https://www.ncbi.nlm.nih.gov/pubmed/36816600
http://dx.doi.org/10.1016/j.mtbio.2023.100566
work_keys_str_mv AT liqianzhe nirresponsivenanoenzymesviaphotothermalablationandhypoxiareversaltopotentiatethestingdependentinnateantitumorimmunity
AT yangmengyu nirresponsivenanoenzymesviaphotothermalablationandhypoxiareversaltopotentiatethestingdependentinnateantitumorimmunity
AT sunxin nirresponsivenanoenzymesviaphotothermalablationandhypoxiareversaltopotentiatethestingdependentinnateantitumorimmunity
AT wangqinxin nirresponsivenanoenzymesviaphotothermalablationandhypoxiareversaltopotentiatethestingdependentinnateantitumorimmunity
AT yubeibei nirresponsivenanoenzymesviaphotothermalablationandhypoxiareversaltopotentiatethestingdependentinnateantitumorimmunity
AT gongaihua nirresponsivenanoenzymesviaphotothermalablationandhypoxiareversaltopotentiatethestingdependentinnateantitumorimmunity
AT zhangmiaomiao nirresponsivenanoenzymesviaphotothermalablationandhypoxiareversaltopotentiatethestingdependentinnateantitumorimmunity
AT dufengyi nirresponsivenanoenzymesviaphotothermalablationandhypoxiareversaltopotentiatethestingdependentinnateantitumorimmunity