Cargando…
New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases
The incidence of obesity and associated metabolic diseases is increasing globally, adversely affecting human health. Dietary fats, especially triglycerides, are an important source of energy for the body, and the intestine absorbs lipids through a series of orderly and complex steps. A long-term hig...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932209/ https://www.ncbi.nlm.nih.gov/pubmed/36817150 http://dx.doi.org/10.3389/fphar.2023.1097835 |
_version_ | 1784889402129907712 |
---|---|
author | Li, Xiaojing Liu, Qiaohong Pan, Yuqing Chen, Si Zhao, Yu Hu, Yiyang |
author_facet | Li, Xiaojing Liu, Qiaohong Pan, Yuqing Chen, Si Zhao, Yu Hu, Yiyang |
author_sort | Li, Xiaojing |
collection | PubMed |
description | The incidence of obesity and associated metabolic diseases is increasing globally, adversely affecting human health. Dietary fats, especially triglycerides, are an important source of energy for the body, and the intestine absorbs lipids through a series of orderly and complex steps. A long-term high-fat diet leads to intestinal dysfunction, inducing obesity and metabolic disorders. Therefore, regulating dietary triglycerides absorption is a promising therapeutic strategy. In this review, we will discuss diverse aspects of the dietary triglycerides hydrolysis, fatty acid uptake, triglycerides resynthesis, chylomicron assembly, trafficking, and secretion processes in intestinal epithelial cells, as well as potential targets in this process that may influence dietary fat-induced obesity and metabolic diseases. We also mention the possible shortcomings and deficiencies in modulating dietary lipid absorption targets to provide a better understanding of their administrability as drugs in obesity and related metabolic disorders. |
format | Online Article Text |
id | pubmed-9932209 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99322092023-02-17 New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases Li, Xiaojing Liu, Qiaohong Pan, Yuqing Chen, Si Zhao, Yu Hu, Yiyang Front Pharmacol Pharmacology The incidence of obesity and associated metabolic diseases is increasing globally, adversely affecting human health. Dietary fats, especially triglycerides, are an important source of energy for the body, and the intestine absorbs lipids through a series of orderly and complex steps. A long-term high-fat diet leads to intestinal dysfunction, inducing obesity and metabolic disorders. Therefore, regulating dietary triglycerides absorption is a promising therapeutic strategy. In this review, we will discuss diverse aspects of the dietary triglycerides hydrolysis, fatty acid uptake, triglycerides resynthesis, chylomicron assembly, trafficking, and secretion processes in intestinal epithelial cells, as well as potential targets in this process that may influence dietary fat-induced obesity and metabolic diseases. We also mention the possible shortcomings and deficiencies in modulating dietary lipid absorption targets to provide a better understanding of their administrability as drugs in obesity and related metabolic disorders. Frontiers Media S.A. 2023-02-02 /pmc/articles/PMC9932209/ /pubmed/36817150 http://dx.doi.org/10.3389/fphar.2023.1097835 Text en Copyright © 2023 Li, Liu, Pan, Chen, Zhao and Hu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Li, Xiaojing Liu, Qiaohong Pan, Yuqing Chen, Si Zhao, Yu Hu, Yiyang New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases |
title | New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases |
title_full | New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases |
title_fullStr | New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases |
title_full_unstemmed | New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases |
title_short | New insights into the role of dietary triglyceride absorption in obesity and metabolic diseases |
title_sort | new insights into the role of dietary triglyceride absorption in obesity and metabolic diseases |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932209/ https://www.ncbi.nlm.nih.gov/pubmed/36817150 http://dx.doi.org/10.3389/fphar.2023.1097835 |
work_keys_str_mv | AT lixiaojing newinsightsintotheroleofdietarytriglycerideabsorptioninobesityandmetabolicdiseases AT liuqiaohong newinsightsintotheroleofdietarytriglycerideabsorptioninobesityandmetabolicdiseases AT panyuqing newinsightsintotheroleofdietarytriglycerideabsorptioninobesityandmetabolicdiseases AT chensi newinsightsintotheroleofdietarytriglycerideabsorptioninobesityandmetabolicdiseases AT zhaoyu newinsightsintotheroleofdietarytriglycerideabsorptioninobesityandmetabolicdiseases AT huyiyang newinsightsintotheroleofdietarytriglycerideabsorptioninobesityandmetabolicdiseases |