Cargando…

Oral granulomatosis with polyangiitis a systematic review

OBJECTIVE: Granulomatosis with polyangiitis is an unusual multisystemic inflammatory disease, with vasculitis of small‐ and medium‐sized vessels, with a predilection for upper lower airways and kidneys. The etiology remains unknown although it may originate from different stimuli, in genetically sus...

Descripción completa

Detalles Bibliográficos
Autores principales: Labrador, Alberto J. Peraza, Valdez, Luciano H. M., Marin, Nestor R. Gonzalez, Ibazetta, Karem A. R., Chacón, Joan A. L., Fernandez, Alberto J. V., Valencia, Marcelo S. V., Marchant, Schillin W., Sanchez, Katman B. T., Villacrez, Cesar A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932239/
https://www.ncbi.nlm.nih.gov/pubmed/36600477
http://dx.doi.org/10.1002/cre2.706
_version_ 1784889409587380224
author Labrador, Alberto J. Peraza
Valdez, Luciano H. M.
Marin, Nestor R. Gonzalez
Ibazetta, Karem A. R.
Chacón, Joan A. L.
Fernandez, Alberto J. V.
Valencia, Marcelo S. V.
Marchant, Schillin W.
Sanchez, Katman B. T.
Villacrez, Cesar A.
author_facet Labrador, Alberto J. Peraza
Valdez, Luciano H. M.
Marin, Nestor R. Gonzalez
Ibazetta, Karem A. R.
Chacón, Joan A. L.
Fernandez, Alberto J. V.
Valencia, Marcelo S. V.
Marchant, Schillin W.
Sanchez, Katman B. T.
Villacrez, Cesar A.
author_sort Labrador, Alberto J. Peraza
collection PubMed
description OBJECTIVE: Granulomatosis with polyangiitis is an unusual multisystemic inflammatory disease, with vasculitis of small‐ and medium‐sized vessels, with a predilection for upper lower airways and kidneys. The etiology remains unknown although it may originate from different stimuli, in genetically susceptible patients. MATERIALS AND METHODS: A detailed database search was performed. The variables were demographics, localization, histopathological findings, antineutrophil cytoplasmic autoantibody, cytoplasmic (c‐ANCA) tests, treatment, and follow‐up. RESULTS: Fifty‐two cases were identified; the mean age was 49.6 years, with a range from 6 to 87 years. It was most frequently seen in females (57.7%). The most common race was white (59.6%). The most frequent location was in the maxillary gingiva (28.8%), followed by both the upper and lower gingiva (19.2%). The most common clinical presentation was “strawberry gingivitis” (61.5%). The main symptom was pain, in 50%. Regarding the c‐ANCA test, it was positive in 71.2% of cases. The most common therapy was prednisone and cyclophosphamide, utilized in 51.9%. The average follow‐up was 23.6 months, and 88.5% of patients were still alive at follow‐up. CONCLUSION: The diagnosis initially was difficult to establish, an early diagnosis and treatment are mandatory. If untreated the disease can be associated with morbidity and mortality. For the oral clinician, this disease needs to be addressed in the differential diagnosis of oral lesions.
format Online
Article
Text
id pubmed-9932239
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-99322392023-02-17 Oral granulomatosis with polyangiitis a systematic review Labrador, Alberto J. Peraza Valdez, Luciano H. M. Marin, Nestor R. Gonzalez Ibazetta, Karem A. R. Chacón, Joan A. L. Fernandez, Alberto J. V. Valencia, Marcelo S. V. Marchant, Schillin W. Sanchez, Katman B. T. Villacrez, Cesar A. Clin Exp Dent Res Review Article OBJECTIVE: Granulomatosis with polyangiitis is an unusual multisystemic inflammatory disease, with vasculitis of small‐ and medium‐sized vessels, with a predilection for upper lower airways and kidneys. The etiology remains unknown although it may originate from different stimuli, in genetically susceptible patients. MATERIALS AND METHODS: A detailed database search was performed. The variables were demographics, localization, histopathological findings, antineutrophil cytoplasmic autoantibody, cytoplasmic (c‐ANCA) tests, treatment, and follow‐up. RESULTS: Fifty‐two cases were identified; the mean age was 49.6 years, with a range from 6 to 87 years. It was most frequently seen in females (57.7%). The most common race was white (59.6%). The most frequent location was in the maxillary gingiva (28.8%), followed by both the upper and lower gingiva (19.2%). The most common clinical presentation was “strawberry gingivitis” (61.5%). The main symptom was pain, in 50%. Regarding the c‐ANCA test, it was positive in 71.2% of cases. The most common therapy was prednisone and cyclophosphamide, utilized in 51.9%. The average follow‐up was 23.6 months, and 88.5% of patients were still alive at follow‐up. CONCLUSION: The diagnosis initially was difficult to establish, an early diagnosis and treatment are mandatory. If untreated the disease can be associated with morbidity and mortality. For the oral clinician, this disease needs to be addressed in the differential diagnosis of oral lesions. John Wiley and Sons Inc. 2023-01-04 /pmc/articles/PMC9932239/ /pubmed/36600477 http://dx.doi.org/10.1002/cre2.706 Text en © 2023 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Labrador, Alberto J. Peraza
Valdez, Luciano H. M.
Marin, Nestor R. Gonzalez
Ibazetta, Karem A. R.
Chacón, Joan A. L.
Fernandez, Alberto J. V.
Valencia, Marcelo S. V.
Marchant, Schillin W.
Sanchez, Katman B. T.
Villacrez, Cesar A.
Oral granulomatosis with polyangiitis a systematic review
title Oral granulomatosis with polyangiitis a systematic review
title_full Oral granulomatosis with polyangiitis a systematic review
title_fullStr Oral granulomatosis with polyangiitis a systematic review
title_full_unstemmed Oral granulomatosis with polyangiitis a systematic review
title_short Oral granulomatosis with polyangiitis a systematic review
title_sort oral granulomatosis with polyangiitis a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932239/
https://www.ncbi.nlm.nih.gov/pubmed/36600477
http://dx.doi.org/10.1002/cre2.706
work_keys_str_mv AT labradoralbertojperaza oralgranulomatosiswithpolyangiitisasystematicreview
AT valdezlucianohm oralgranulomatosiswithpolyangiitisasystematicreview
AT marinnestorrgonzalez oralgranulomatosiswithpolyangiitisasystematicreview
AT ibazettakaremar oralgranulomatosiswithpolyangiitisasystematicreview
AT chaconjoanal oralgranulomatosiswithpolyangiitisasystematicreview
AT fernandezalbertojv oralgranulomatosiswithpolyangiitisasystematicreview
AT valenciamarcelosv oralgranulomatosiswithpolyangiitisasystematicreview
AT marchantschillinw oralgranulomatosiswithpolyangiitisasystematicreview
AT sanchezkatmanbt oralgranulomatosiswithpolyangiitisasystematicreview
AT villacrezcesara oralgranulomatosiswithpolyangiitisasystematicreview