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The glycine N-acyltransferases, GLYAT and GLYATL1, contribute to the detoxification of isovaleryl-CoA - an in-silico and in vitro validation

Isovaleric acidemia (IVA), due to isovaleryl-CoA dehydrogenase (IVD) deficiency, results in the accumulation of isovaleryl-CoA, isovaleric acid and secondary metabolites. The increase in these metabolites decreases mitochondrial energy production and increases oxidative stress. This contributes to t...

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Detalles Bibliográficos
Autores principales:	Kühn, Stefan, Williams, Monray E., Dercksen, Marli, Sass, Jörn Oliver, van der Sluis, Rencia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Research Network of Computational and Structural Biotechnology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932296/ https://www.ncbi.nlm.nih.gov/pubmed/36817957 http://dx.doi.org/10.1016/j.csbj.2023.01.041

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