In vitro to in vivo acetaminophen hepatotoxicity extrapolation using classical schemes, pharmacodynamic models and a multiscale spatial-temporal liver twin

In vitro to in vivo extrapolation represents a critical challenge in toxicology. In this paper we explore extrapolation strategies for acetaminophen (APAP) based on mechanistic models, comparing classical (CL) homogeneous compartment pharmacodynamic (PD) models and a spatial-temporal (ST), multiscal...

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Detalles Bibliográficos
Autores principales: Dichamp, Jules, Cellière, Geraldine, Ghallab, Ahmed, Hassan, Reham, Boissier, Noemie, Hofmann, Ute, Reinders, Joerg, Sezgin, Selahaddin, Zühlke, Sebastian, Hengstler, Jan G., Drasdo, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932319/
https://www.ncbi.nlm.nih.gov/pubmed/36815881
http://dx.doi.org/10.3389/fbioe.2023.1049564

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