Impact of genetic variants involved in the lipid metabolism pathway on progression free survival in patients receiving bevacizumab-based chemotherapy in metastatic colorectal cancer: a retrospective analysis of FIRE-3 and MAVERICC trials

BACKGROUND: Antiangiogenic drug (AAD)-triggered oxygen and nutrient depletion through suppression of angiogenesis switches glucose-dependent to lipid-dependent metabolism. Blocking fatty acid oxidation can enhance AAD-mediated anti-tumor effects in colorectal cancer (CRC). Therefore, we hypothesised...

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Detalles Bibliográficos
Autores principales: Wang, Jingyuan, Millstein, Joshua, Yang, Yan, Stintzing, Sebastian, Arai, Hiroyuki, Battaglin, Francesca, Kawanishi, Natsuko, Soni, Shivani, Zhang, Wu, Mancao, Christoph, Cremolini, Chiara, Liu, Tianshu, Heinemann, Volker, Falcone, Alfredo, Shen, Lin, Lenz, Heinz-Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932345/
https://www.ncbi.nlm.nih.gov/pubmed/36816347
http://dx.doi.org/10.1016/j.eclinm.2023.101827

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932345/
https://www.ncbi.nlm.nih.gov/pubmed/36816347
http://dx.doi.org/10.1016/j.eclinm.2023.101827

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