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Gene expression data visualization tool on the o²S²PARC platform

Background: The identification of differentially expressed genes and their associated biological processes, molecular function, and cellular components are essential for genetic disease studies because they present potential biomarkers and therapeutic targets. Methods: In this study, we developed an...

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Detalles Bibliográficos
Autores principales: Ben Aribi, Hiba, Ding, Mengyuan, Kiran, Anmol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932352/
https://www.ncbi.nlm.nih.gov/pubmed/36816807
http://dx.doi.org/10.12688/f1000research.126840.2
Descripción
Sumario:Background: The identification of differentially expressed genes and their associated biological processes, molecular function, and cellular components are essential for genetic disease studies because they present potential biomarkers and therapeutic targets. Methods: In this study, we developed an o²S²PARC template to instantiate an interactive pipeline for gene expression data visualization, ontological mapping, and statistical evaluation. To demonstrate the tool's usefulness, we performed a case study on a publicly available dataset. Results: The tool enables users to identify the differentially expressed genes (DEGs) and visualize them in a volcano plot format. Ontologies associated with the DEGs are assigned and visualized in barplots. Conclusions: The “Expression data visualization” template is publicly available on the o²S²PARC platform.