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Gene expression data visualization tool on the o²S²PARC platform

Background: The identification of differentially expressed genes and their associated biological processes, molecular function, and cellular components are essential for genetic disease studies because they present potential biomarkers and therapeutic targets. Methods: In this study, we developed an...

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Detalles Bibliográficos
Autores principales: Ben Aribi, Hiba, Ding, Mengyuan, Kiran, Anmol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932352/
https://www.ncbi.nlm.nih.gov/pubmed/36816807
http://dx.doi.org/10.12688/f1000research.126840.2
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author Ben Aribi, Hiba
Ding, Mengyuan
Kiran, Anmol
author_facet Ben Aribi, Hiba
Ding, Mengyuan
Kiran, Anmol
author_sort Ben Aribi, Hiba
collection PubMed
description Background: The identification of differentially expressed genes and their associated biological processes, molecular function, and cellular components are essential for genetic disease studies because they present potential biomarkers and therapeutic targets. Methods: In this study, we developed an o²S²PARC template to instantiate an interactive pipeline for gene expression data visualization, ontological mapping, and statistical evaluation. To demonstrate the tool's usefulness, we performed a case study on a publicly available dataset. Results: The tool enables users to identify the differentially expressed genes (DEGs) and visualize them in a volcano plot format. Ontologies associated with the DEGs are assigned and visualized in barplots. Conclusions: The “Expression data visualization” template is publicly available on the o²S²PARC platform.
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spelling pubmed-99323522023-02-17 Gene expression data visualization tool on the o²S²PARC platform Ben Aribi, Hiba Ding, Mengyuan Kiran, Anmol F1000Res Software Tool Article Background: The identification of differentially expressed genes and their associated biological processes, molecular function, and cellular components are essential for genetic disease studies because they present potential biomarkers and therapeutic targets. Methods: In this study, we developed an o²S²PARC template to instantiate an interactive pipeline for gene expression data visualization, ontological mapping, and statistical evaluation. To demonstrate the tool's usefulness, we performed a case study on a publicly available dataset. Results: The tool enables users to identify the differentially expressed genes (DEGs) and visualize them in a volcano plot format. Ontologies associated with the DEGs are assigned and visualized in barplots. Conclusions: The “Expression data visualization” template is publicly available on the o²S²PARC platform. F1000 Research Limited 2023-02-06 /pmc/articles/PMC9932352/ /pubmed/36816807 http://dx.doi.org/10.12688/f1000research.126840.2 Text en Copyright: © 2023 Ben Aribi H et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Software Tool Article
Ben Aribi, Hiba
Ding, Mengyuan
Kiran, Anmol
Gene expression data visualization tool on the o²S²PARC platform
title Gene expression data visualization tool on the o²S²PARC platform
title_full Gene expression data visualization tool on the o²S²PARC platform
title_fullStr Gene expression data visualization tool on the o²S²PARC platform
title_full_unstemmed Gene expression data visualization tool on the o²S²PARC platform
title_short Gene expression data visualization tool on the o²S²PARC platform
title_sort gene expression data visualization tool on the o²s²parc platform
topic Software Tool Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932352/
https://www.ncbi.nlm.nih.gov/pubmed/36816807
http://dx.doi.org/10.12688/f1000research.126840.2
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