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Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy

Tumor microbiota is a group of microorganisms located in tumor tissues with rich diversity that can promote tumorigenesis and development, and different types of tumors have different tumor microbiotas, which has important implications for tumor research, detection, and clinical treatment. In this r...

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Detalles Bibliográficos
Autores principales: Zheng, Heng, Chen, Xianxian, Li, Qiyang, Liu, Yuqi, Cai, Jinzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932492/
https://www.ncbi.nlm.nih.gov/pubmed/36817477
http://dx.doi.org/10.3389/fimmu.2023.1084926
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author Zheng, Heng
Chen, Xianxian
Li, Qiyang
Liu, Yuqi
Cai, Jinzhong
author_facet Zheng, Heng
Chen, Xianxian
Li, Qiyang
Liu, Yuqi
Cai, Jinzhong
author_sort Zheng, Heng
collection PubMed
description Tumor microbiota is a group of microorganisms located in tumor tissues with rich diversity that can promote tumorigenesis and development, and different types of tumors have different tumor microbiotas, which has important implications for tumor research, detection, and clinical treatment. In this review, we examine the diversity of the tumor microbiota, discuss the impact of chemotherapy and immunotherapy on tumor microbiota diversity, and summarize recent advances in the use of genetically engineered bacteria for the treatment of tumors. In addition, we propose key questions that need to be further addressed by the tumor microbiota.
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spelling pubmed-99324922023-02-17 Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy Zheng, Heng Chen, Xianxian Li, Qiyang Liu, Yuqi Cai, Jinzhong Front Immunol Immunology Tumor microbiota is a group of microorganisms located in tumor tissues with rich diversity that can promote tumorigenesis and development, and different types of tumors have different tumor microbiotas, which has important implications for tumor research, detection, and clinical treatment. In this review, we examine the diversity of the tumor microbiota, discuss the impact of chemotherapy and immunotherapy on tumor microbiota diversity, and summarize recent advances in the use of genetically engineered bacteria for the treatment of tumors. In addition, we propose key questions that need to be further addressed by the tumor microbiota. Frontiers Media S.A. 2023-02-02 /pmc/articles/PMC9932492/ /pubmed/36817477 http://dx.doi.org/10.3389/fimmu.2023.1084926 Text en Copyright © 2023 Zheng, Chen, Li, Liu and Cai https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zheng, Heng
Chen, Xianxian
Li, Qiyang
Liu, Yuqi
Cai, Jinzhong
Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy
title Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy
title_full Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy
title_fullStr Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy
title_full_unstemmed Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy
title_short Effects of chemotherapy and immunotherapy on microbial diversity in TME and engineered bacterial-mediated tumor therapy
title_sort effects of chemotherapy and immunotherapy on microbial diversity in tme and engineered bacterial-mediated tumor therapy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932492/
https://www.ncbi.nlm.nih.gov/pubmed/36817477
http://dx.doi.org/10.3389/fimmu.2023.1084926
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