Case report: Preclinical efficacy of NEDD8 and proteasome inhibitors in patient-derived models of signet ring high-grade mucinous colorectal cancer from a Lynch syndrome patient

High-grade mucinous colorectal cancer (HGM CRC) is particularly aggressive, prone to metastasis and treatment resistance, frequently accompanied by “signet ring” cancer cells. A sizeable fraction of HGM CRCs (20-40%) arises in the context of the Lynch Syndrome, an autosomal hereditary syndrome that...

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Detalles Bibliográficos
Autores principales: Torchiaro, Erica, Petti, Consalvo, Arena, Sabrina, Sassi, Francesco, Migliardi, Giorgia, Mellano, Alfredo, Porporato, Roberta, Basiricò, Marco, Gammaitoni, Loretta, Berrino, Enrico, Montone, Monica, Corti, Giorgio, Crisafulli, Giovanni, Marchiò, Caterina, Bardelli, Alberto, Medico, Enzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932521/
https://www.ncbi.nlm.nih.gov/pubmed/36816936
http://dx.doi.org/10.3389/fonc.2023.1130852

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