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Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma

Oral squamous cell carcinoma (OSCC) is the eighth most common type of cancer in the world. Knowledge of prognostic factors of survival in OSCC is key. Several clinical and pathological prognostic factors have been investigated to develop a prognostic model of survival for patients with oral cancer....

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Autores principales: Mijatov, Ivana, Kiralj, Aleksandar, Ilić, Miroslav P., Vučković, Nada, Spasić, Aleksandar, Nikolić, Jelena, Tadić, Ana, Mijatov, Saša
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932573/
https://www.ncbi.nlm.nih.gov/pubmed/36817058
http://dx.doi.org/10.3892/ol.2023.13679
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author Mijatov, Ivana
Kiralj, Aleksandar
Ilić, Miroslav P.
Vučković, Nada
Spasić, Aleksandar
Nikolić, Jelena
Tadić, Ana
Mijatov, Saša
author_facet Mijatov, Ivana
Kiralj, Aleksandar
Ilić, Miroslav P.
Vučković, Nada
Spasić, Aleksandar
Nikolić, Jelena
Tadić, Ana
Mijatov, Saša
author_sort Mijatov, Ivana
collection PubMed
description Oral squamous cell carcinoma (OSCC) is the eighth most common type of cancer in the world. Knowledge of prognostic factors of survival in OSCC is key. Several clinical and pathological prognostic factors have been investigated to develop a prognostic model of survival for patients with oral cancer. The present study focused on the association between pathological tumor volume (PTV) and overall survival time in patients with OSCC, regardless of cervical nodal status. The present study was a prospective study and covered 65 consecutive patients who received surgical treatment for oral cancer. The PTV was calculated according to dimensions of the postoperative specimen. Other pathological parameters as perineural and perivascular tumor spreading and extra-nodular propagation were also determined. The data were analyzed using the IBM SPSS 25.0 software. Cox PH regression model was built to analyze association between the PTV and survival time. Survival time was defined as the period from surgery to a target event or last contact. The results of the present study showed that PTV >4.24 cm(3) was significantly associated with shorter overall survival time in patients with OSCC. The PTV value was higher in patients with metastasis and in patients with higher pathological tumor and node stage. In conclusion, PTV was an important pathological prognostic factor for survival in patients with OSCC.
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spelling pubmed-99325732023-02-17 Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma Mijatov, Ivana Kiralj, Aleksandar Ilić, Miroslav P. Vučković, Nada Spasić, Aleksandar Nikolić, Jelena Tadić, Ana Mijatov, Saša Oncol Lett Articles Oral squamous cell carcinoma (OSCC) is the eighth most common type of cancer in the world. Knowledge of prognostic factors of survival in OSCC is key. Several clinical and pathological prognostic factors have been investigated to develop a prognostic model of survival for patients with oral cancer. The present study focused on the association between pathological tumor volume (PTV) and overall survival time in patients with OSCC, regardless of cervical nodal status. The present study was a prospective study and covered 65 consecutive patients who received surgical treatment for oral cancer. The PTV was calculated according to dimensions of the postoperative specimen. Other pathological parameters as perineural and perivascular tumor spreading and extra-nodular propagation were also determined. The data were analyzed using the IBM SPSS 25.0 software. Cox PH regression model was built to analyze association between the PTV and survival time. Survival time was defined as the period from surgery to a target event or last contact. The results of the present study showed that PTV >4.24 cm(3) was significantly associated with shorter overall survival time in patients with OSCC. The PTV value was higher in patients with metastasis and in patients with higher pathological tumor and node stage. In conclusion, PTV was an important pathological prognostic factor for survival in patients with OSCC. D.A. Spandidos 2023-01-25 /pmc/articles/PMC9932573/ /pubmed/36817058 http://dx.doi.org/10.3892/ol.2023.13679 Text en Copyright: © Mijatov et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Mijatov, Ivana
Kiralj, Aleksandar
Ilić, Miroslav P.
Vučković, Nada
Spasić, Aleksandar
Nikolić, Jelena
Tadić, Ana
Mijatov, Saša
Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma
title Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma
title_full Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma
title_fullStr Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma
title_full_unstemmed Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma
title_short Pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma
title_sort pathological tumor volume as a simple quantitative predictive factor of survival in oral squamous cell carcinoma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932573/
https://www.ncbi.nlm.nih.gov/pubmed/36817058
http://dx.doi.org/10.3892/ol.2023.13679
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