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Redirecting Polyclonal T Cells against Cancer with Soluble T-Cell Receptors
Cancer cells accumulate genetic mutations in coding proteins that may be presented by HLA as neoantigenic peptides (peptide HLA, pHLA). T cells scan for neoantigenic pHLA by the T-cell receptor (TCR):CD3 complex. This complex has the dual function of binding pHLA, by the TCR, and triggering T-cell a...
Autores principales: | Berman, David M., Bell, John I. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932579/ https://www.ncbi.nlm.nih.gov/pubmed/36255733 http://dx.doi.org/10.1158/1078-0432.CCR-22-0028 |
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