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Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice
Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient’s life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiqui...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932705/ https://www.ncbi.nlm.nih.gov/pubmed/36816313 http://dx.doi.org/10.1016/j.heliyon.2023.e13337 |
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author | Wen, Kang Li, Wu Cheng, Chen Weige, Xie Jiaqi, Chen Shiyu, Song Lingyan, Huang Hongwei, Wang Sijing, Xie |
author_facet | Wen, Kang Li, Wu Cheng, Chen Weige, Xie Jiaqi, Chen Shiyu, Song Lingyan, Huang Hongwei, Wang Sijing, Xie |
author_sort | Wen, Kang |
collection | PubMed |
description | Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient’s life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiquimod (IMQ)-induced psoriasis in mice. The psoriasis model was established by topical application of IMQ cream in mice for 7 days. We found that subcutaneous injection of hDPSC could reduce the symptoms of skin lesions in IMQ-induced psoriasis and suppress the expression of keratin 16, S100A8, S100A9, which are associated with abnormal epidermal proliferation. Subepithelial inflammatory cytokines, CD4(+) T lymphocytes and CD11c(+) dendritic cells infiltrations were significantly inhibited in by hDPSC. The TNF-α, IFN-γ expressions in serum were decreased, and splenomegaly induced by IMQ was improved after hDPSC treatment. In summary, our study demonstrated that hDPSC could reduce the symptoms of skin lesions and suppress local and systemic immune responses of IMQ-induced psoriasis in mice, which might provide a new sight for the treatment of psoriasis. |
format | Online Article Text |
id | pubmed-9932705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-99327052023-02-17 Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice Wen, Kang Li, Wu Cheng, Chen Weige, Xie Jiaqi, Chen Shiyu, Song Lingyan, Huang Hongwei, Wang Sijing, Xie Heliyon Research Article Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient’s life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiquimod (IMQ)-induced psoriasis in mice. The psoriasis model was established by topical application of IMQ cream in mice for 7 days. We found that subcutaneous injection of hDPSC could reduce the symptoms of skin lesions in IMQ-induced psoriasis and suppress the expression of keratin 16, S100A8, S100A9, which are associated with abnormal epidermal proliferation. Subepithelial inflammatory cytokines, CD4(+) T lymphocytes and CD11c(+) dendritic cells infiltrations were significantly inhibited in by hDPSC. The TNF-α, IFN-γ expressions in serum were decreased, and splenomegaly induced by IMQ was improved after hDPSC treatment. In summary, our study demonstrated that hDPSC could reduce the symptoms of skin lesions and suppress local and systemic immune responses of IMQ-induced psoriasis in mice, which might provide a new sight for the treatment of psoriasis. Elsevier 2023-02-01 /pmc/articles/PMC9932705/ /pubmed/36816313 http://dx.doi.org/10.1016/j.heliyon.2023.e13337 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Wen, Kang Li, Wu Cheng, Chen Weige, Xie Jiaqi, Chen Shiyu, Song Lingyan, Huang Hongwei, Wang Sijing, Xie Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice |
title | Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice |
title_full | Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice |
title_fullStr | Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice |
title_full_unstemmed | Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice |
title_short | Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice |
title_sort | human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932705/ https://www.ncbi.nlm.nih.gov/pubmed/36816313 http://dx.doi.org/10.1016/j.heliyon.2023.e13337 |
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