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Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice

Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient’s life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiqui...

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Autores principales: Wen, Kang, Li, Wu, Cheng, Chen, Weige, Xie, Jiaqi, Chen, Shiyu, Song, Lingyan, Huang, Hongwei, Wang, Sijing, Xie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932705/
https://www.ncbi.nlm.nih.gov/pubmed/36816313
http://dx.doi.org/10.1016/j.heliyon.2023.e13337
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author Wen, Kang
Li, Wu
Cheng, Chen
Weige, Xie
Jiaqi, Chen
Shiyu, Song
Lingyan, Huang
Hongwei, Wang
Sijing, Xie
author_facet Wen, Kang
Li, Wu
Cheng, Chen
Weige, Xie
Jiaqi, Chen
Shiyu, Song
Lingyan, Huang
Hongwei, Wang
Sijing, Xie
author_sort Wen, Kang
collection PubMed
description Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient’s life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiquimod (IMQ)-induced psoriasis in mice. The psoriasis model was established by topical application of IMQ cream in mice for 7 days. We found that subcutaneous injection of hDPSC could reduce the symptoms of skin lesions in IMQ-induced psoriasis and suppress the expression of keratin 16, S100A8, S100A9, which are associated with abnormal epidermal proliferation. Subepithelial inflammatory cytokines, CD4(+) T lymphocytes and CD11c(+) dendritic cells infiltrations were significantly inhibited in by hDPSC. The TNF-α, IFN-γ expressions in serum were decreased, and splenomegaly induced by IMQ was improved after hDPSC treatment. In summary, our study demonstrated that hDPSC could reduce the symptoms of skin lesions and suppress local and systemic immune responses of IMQ-induced psoriasis in mice, which might provide a new sight for the treatment of psoriasis.
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spelling pubmed-99327052023-02-17 Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice Wen, Kang Li, Wu Cheng, Chen Weige, Xie Jiaqi, Chen Shiyu, Song Lingyan, Huang Hongwei, Wang Sijing, Xie Heliyon Research Article Psoriasis is an autoimmune disease, which has a significant impact on the quality of patient’s life. And, there is still no cure for psoriasis. The human dental pulp stem cell (hDPSC) possesses the properties of immunoregulation. In this study, we aimed to determine the effect of hDPSC on the imiquimod (IMQ)-induced psoriasis in mice. The psoriasis model was established by topical application of IMQ cream in mice for 7 days. We found that subcutaneous injection of hDPSC could reduce the symptoms of skin lesions in IMQ-induced psoriasis and suppress the expression of keratin 16, S100A8, S100A9, which are associated with abnormal epidermal proliferation. Subepithelial inflammatory cytokines, CD4(+) T lymphocytes and CD11c(+) dendritic cells infiltrations were significantly inhibited in by hDPSC. The TNF-α, IFN-γ expressions in serum were decreased, and splenomegaly induced by IMQ was improved after hDPSC treatment. In summary, our study demonstrated that hDPSC could reduce the symptoms of skin lesions and suppress local and systemic immune responses of IMQ-induced psoriasis in mice, which might provide a new sight for the treatment of psoriasis. Elsevier 2023-02-01 /pmc/articles/PMC9932705/ /pubmed/36816313 http://dx.doi.org/10.1016/j.heliyon.2023.e13337 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Wen, Kang
Li, Wu
Cheng, Chen
Weige, Xie
Jiaqi, Chen
Shiyu, Song
Lingyan, Huang
Hongwei, Wang
Sijing, Xie
Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice
title Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice
title_full Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice
title_fullStr Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice
title_full_unstemmed Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice
title_short Human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice
title_sort human dental pulp stem cells ameliorate the imiquimod-induced psoriasis in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932705/
https://www.ncbi.nlm.nih.gov/pubmed/36816313
http://dx.doi.org/10.1016/j.heliyon.2023.e13337
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