Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)

Long non-coding RNAs (lncRNAs) are a class of RNAs that are >200 nucleotides in length that do not have the ability to be translated into protein but are associated with numerous diseases, including cancer. The involvement of lncRNAs in the signalling of certain signalling pathways can promote tu...

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Autores principales: Hu, Zhizhong, Liu, Yitong, Liu, Meiqi, Zhang, Yang, Wang, Chengkun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932718/
https://www.ncbi.nlm.nih.gov/pubmed/36817052
http://dx.doi.org/10.3892/ol.2023.13693
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author Hu, Zhizhong
Liu, Yitong
Liu, Meiqi
Zhang, Yang
Wang, Chengkun
author_facet Hu, Zhizhong
Liu, Yitong
Liu, Meiqi
Zhang, Yang
Wang, Chengkun
author_sort Hu, Zhizhong
collection PubMed
description Long non-coding RNAs (lncRNAs) are a class of RNAs that are >200 nucleotides in length that do not have the ability to be translated into protein but are associated with numerous diseases, including cancer. The involvement of lncRNAs in the signalling of certain signalling pathways can promote tumour progression; these pathways include the transforming growth factor (TGF)-β signalling pathway, which is related to tumour development. The expression of lncRNAs in various tumour tissues is specific, and their interaction with the TGF-β signalling pathway indicates that they may serve as new tumour markers and therapeutic targets. The present review summarized the role of TGF-β pathway-associated lncRNAs in regulating tumorigenesis in different types of cancer and their effects on the TGF-β signalling pathway.
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spelling pubmed-99327182023-02-17 Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review) Hu, Zhizhong Liu, Yitong Liu, Meiqi Zhang, Yang Wang, Chengkun Oncol Lett Review Long non-coding RNAs (lncRNAs) are a class of RNAs that are >200 nucleotides in length that do not have the ability to be translated into protein but are associated with numerous diseases, including cancer. The involvement of lncRNAs in the signalling of certain signalling pathways can promote tumour progression; these pathways include the transforming growth factor (TGF)-β signalling pathway, which is related to tumour development. The expression of lncRNAs in various tumour tissues is specific, and their interaction with the TGF-β signalling pathway indicates that they may serve as new tumour markers and therapeutic targets. The present review summarized the role of TGF-β pathway-associated lncRNAs in regulating tumorigenesis in different types of cancer and their effects on the TGF-β signalling pathway. D.A. Spandidos 2023-02-02 /pmc/articles/PMC9932718/ /pubmed/36817052 http://dx.doi.org/10.3892/ol.2023.13693 Text en Copyright: © Hu et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Review
Hu, Zhizhong
Liu, Yitong
Liu, Meiqi
Zhang, Yang
Wang, Chengkun
Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)
title Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)
title_full Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)
title_fullStr Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)
title_full_unstemmed Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)
title_short Roles of TGF‑β signalling pathway‑related lncRNAs in cancer (Review)
title_sort roles of tgf‑β signalling pathway‑related lncrnas in cancer (review)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932718/
https://www.ncbi.nlm.nih.gov/pubmed/36817052
http://dx.doi.org/10.3892/ol.2023.13693
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