The PRMT5 inhibitor EPZ015666 is effective against HTLV-1-transformed T-cell lines in vitro and in vivo

Human T-cell leukemia virus type 1 (HTLV-1) is the infectious cause of adult T-cell leukemia/lymphoma (ATL), an extremely aggressive and fatal malignancy of CD4(+) T-cells. Due to the chemotherapy-resistance of ATL and the absence of long-term therapy regimens currently available for ATL patients, t...

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Detalles Bibliográficos
Autores principales: Ernzen, Kyle, Melvin, Corrine, Yu, Lianbo, Phelps, Cameron, Niewiesk, Stefan, Green, Patrick L., Panfil, Amanda R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932813/
https://www.ncbi.nlm.nih.gov/pubmed/36819050
http://dx.doi.org/10.3389/fmicb.2023.1101544

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