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GMP development and preclinical validation of CAR-T cells targeting a lytic EBV antigen for therapy of EBV-associated malignancies

INTRODUCTION: Epstein-Barr virus (EBV) is a widely spread pathogen associated with lymphoproliferative diseases, B/ T/ NK cell lymphomas, nasopharyngeal carcinoma (NPC) and gastric carcinoma (GC). EBV lytic reactivations contribute to the genomic instability, inflammation and tumorigenesis of NPC, p...

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Detalles Bibliográficos
Autores principales:	Zhang, Xi, Wang, Tiaoxia, Zhu, Xiaona, Lu, Yong, Li, Mingpeng, Huang, Zhihong, Han, Deping, Zhang, Longzhen, Wu, Yang, Li, Liantao, Klawonn, Frank, Stripecke, Renata
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932894/ https://www.ncbi.nlm.nih.gov/pubmed/36817460 http://dx.doi.org/10.3389/fimmu.2023.1103695

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