The Get1/2 insertase forms a channel to mediate the insertion of tail-anchored proteins into the ER

Tail-anchored (TA) proteins contain a single C-terminal transmembrane domain (TMD) that is captured by the cytosolic Get3 in yeast (TRC40 in humans). Get3 delivers TA proteins to the Get1/2 complex for insertion into the endoplasmic reticulum (ER) membrane. How Get1/2 mediates insertion of TMDs of T...

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Detalles Bibliográficos
Autores principales: Heo, Paul, Culver, Jacob A., Miao, Jennifer, Pincet, Frederic, Mariappan, Malaiyalam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932932/
https://www.ncbi.nlm.nih.gov/pubmed/36640319
http://dx.doi.org/10.1016/j.celrep.2022.111921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932932/
https://www.ncbi.nlm.nih.gov/pubmed/36640319
http://dx.doi.org/10.1016/j.celrep.2022.111921

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