The human inactive X chromosome modulates expression of the active X chromosome

The “inactive” X chromosome (Xi) has been assumed to have little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xis. Our linear modeling revealed modular Xi and Xa transcriptomes and significant Xi-driven e...

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Detalles Bibliográficos
Autores principales: San Roman, Adrianna K., Godfrey, Alexander K., Skaletsky, Helen, Bellott, Daniel W., Groff, Abigail F., Harris, Hannah L., Blanton, Laura V., Hughes, Jennifer F., Brown, Laura, Phou, Sidaly, Buscetta, Ashley, Kruszka, Paul, Banks, Nicole, Dutra, Amalia, Pak, Evgenia, Lasutschinkow, Patricia C., Keen, Colleen, Davis, Shanlee M., Tartaglia, Nicole R., Samango-Sprouse, Carole, Muenke, Maximilian, Page, David C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9932992/
https://www.ncbi.nlm.nih.gov/pubmed/36819663
http://dx.doi.org/10.1016/j.xgen.2023.100259

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