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Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project
BACKGROUND: Atrial fibrillation (AF) is an uncommon arrhythmia in young adults without structural heart disease, and cryoballoon pulmonary vein isolation (CB‐PVI) is an important therapeutic strategy for rhythm control in patients with drug‐refractory AF. The aim of this analysis was to evaluate eff...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933101/ https://www.ncbi.nlm.nih.gov/pubmed/36448243 http://dx.doi.org/10.1002/clc.23951 |
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author | Bertaglia, Emanuele Iacopino, Saverio Verlato, Roberto Arena, Giuseppe Pieragnoli, Paolo Tondo, Claudio Molon, Giulio Manfrin, Massimiliano Perego, Giovanni B. Rovaris, Giovanni Rivezzi, Francesco Mantica, Massimo Startari, Umberto Sciarra, Luigi |
author_facet | Bertaglia, Emanuele Iacopino, Saverio Verlato, Roberto Arena, Giuseppe Pieragnoli, Paolo Tondo, Claudio Molon, Giulio Manfrin, Massimiliano Perego, Giovanni B. Rovaris, Giovanni Rivezzi, Francesco Mantica, Massimo Startari, Umberto Sciarra, Luigi |
author_sort | Bertaglia, Emanuele |
collection | PubMed |
description | BACKGROUND: Atrial fibrillation (AF) is an uncommon arrhythmia in young adults without structural heart disease, and cryoballoon pulmonary vein isolation (CB‐PVI) is an important therapeutic strategy for rhythm control in patients with drug‐refractory AF. The aim of this analysis was to evaluate efficacy and safety of CB‐PVI in a large cohort of young patients in comparison with middle‐aged adults in a real‐world setting. METHODS: From 2012 to 2020, a total of 3033 patients with AF underwent CB‐PVI and were followed prospectively in the framework of the 1STOP Clinical Service project, involving 34 Italian centers. Out of 3033 total 1STOP project subjects, a subgroup of 1318 patients were defined which included a YOUNG group (age ≤ 45 years; n = 368) and a MIDDLE‐AGED group (age 60–65 years; n = 950). RESULTS: The acute success rate of PVI did not differ between the two cohorts (99.9 ± 1.3% vs. 99.8 ± 3.2%, p = 0.415). There was no difference in procedural characteristics, and periprocedural complication rates were similar among the two cohort (1.9% vs. 2.3%, p = 0.646). The 12‐month freedom from AF recurrence was 88.9% (95% confidence interval [CI]: 84.7–92.0) in the YOUNG cohort and 85.6% (95% CI: 82.9–88.0) in the MIDDLE‐AGED group. At 36‐month follow‐up, freedom from AF recurrence was 72.4% (65.5%–78.2%) and 71.8% (67.7%–75.6%), respectively with no significant difference among groups (p = 0.550). CONCLUSION: CB‐PVI had similar efficacy and safety in YOUNG and MIDDLE‐AGED patients. Younger age did not affect acute procedural results, complication rate, or AF recurrence after a single procedure. |
format | Online Article Text |
id | pubmed-9933101 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99331012023-02-17 Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project Bertaglia, Emanuele Iacopino, Saverio Verlato, Roberto Arena, Giuseppe Pieragnoli, Paolo Tondo, Claudio Molon, Giulio Manfrin, Massimiliano Perego, Giovanni B. Rovaris, Giovanni Rivezzi, Francesco Mantica, Massimo Startari, Umberto Sciarra, Luigi Clin Cardiol Clinical Investigations BACKGROUND: Atrial fibrillation (AF) is an uncommon arrhythmia in young adults without structural heart disease, and cryoballoon pulmonary vein isolation (CB‐PVI) is an important therapeutic strategy for rhythm control in patients with drug‐refractory AF. The aim of this analysis was to evaluate efficacy and safety of CB‐PVI in a large cohort of young patients in comparison with middle‐aged adults in a real‐world setting. METHODS: From 2012 to 2020, a total of 3033 patients with AF underwent CB‐PVI and were followed prospectively in the framework of the 1STOP Clinical Service project, involving 34 Italian centers. Out of 3033 total 1STOP project subjects, a subgroup of 1318 patients were defined which included a YOUNG group (age ≤ 45 years; n = 368) and a MIDDLE‐AGED group (age 60–65 years; n = 950). RESULTS: The acute success rate of PVI did not differ between the two cohorts (99.9 ± 1.3% vs. 99.8 ± 3.2%, p = 0.415). There was no difference in procedural characteristics, and periprocedural complication rates were similar among the two cohort (1.9% vs. 2.3%, p = 0.646). The 12‐month freedom from AF recurrence was 88.9% (95% confidence interval [CI]: 84.7–92.0) in the YOUNG cohort and 85.6% (95% CI: 82.9–88.0) in the MIDDLE‐AGED group. At 36‐month follow‐up, freedom from AF recurrence was 72.4% (65.5%–78.2%) and 71.8% (67.7%–75.6%), respectively with no significant difference among groups (p = 0.550). CONCLUSION: CB‐PVI had similar efficacy and safety in YOUNG and MIDDLE‐AGED patients. Younger age did not affect acute procedural results, complication rate, or AF recurrence after a single procedure. John Wiley and Sons Inc. 2022-11-29 /pmc/articles/PMC9933101/ /pubmed/36448243 http://dx.doi.org/10.1002/clc.23951 Text en © 2022 The Authors. Clinical Cardiology published by Wiley Periodicals, LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Investigations Bertaglia, Emanuele Iacopino, Saverio Verlato, Roberto Arena, Giuseppe Pieragnoli, Paolo Tondo, Claudio Molon, Giulio Manfrin, Massimiliano Perego, Giovanni B. Rovaris, Giovanni Rivezzi, Francesco Mantica, Massimo Startari, Umberto Sciarra, Luigi Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project |
title | Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project |
title_full | Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project |
title_fullStr | Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project |
title_full_unstemmed | Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project |
title_short | Safety and efficacy of cryoablation for atrial fibrillation in young patients: A multicenter experience in the 1STOP project |
title_sort | safety and efficacy of cryoablation for atrial fibrillation in young patients: a multicenter experience in the 1stop project |
topic | Clinical Investigations |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933101/ https://www.ncbi.nlm.nih.gov/pubmed/36448243 http://dx.doi.org/10.1002/clc.23951 |
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