Cytochrome P450 metabolism studies of [6]-gingerol, [8]-gingerol, and [10]-gingerol by liver microsomes of humans and different species combined with expressed CYP enzymes

Gingerols, mainly [6]-gingerol (6G), [8]-gingerol (8G), and [10]-gingerol (10G), are the functional and specific pungent phytochemicals in ginger. However, poor oral bioavailability limits their applications owing to extensive metabolism. The present study aims to characterize the cytochrome P450 (C...

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Detalles Bibliográficos
Autores principales: Chen, Chanjuan, Chen, Xintong, Mo, Qingmei, Liu, Jie, Yao, Xinsheng, Di, Xin, Qin, Zifei, He, Liangliang, Yao, Zhihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933181/
https://www.ncbi.nlm.nih.gov/pubmed/36816071
http://dx.doi.org/10.1039/d2ra06184h

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