DNA methylation entropy as a measure of stem cell replication and aging

BACKGROUND: Epigenetic marks are encoded by DNA methylation and accumulate errors as organisms age. This drift correlates with lifespan, but the biology of how this occurs is still unexplained. We analyze DNA methylation with age in mouse intestinal stem cells and compare them to nonstem cells. RESU...

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Detalles Bibliográficos
Autores principales: Vaidya, Himani, Jeong, Hye Seon, Keith, Kelsey, Maegawa, Shinji, Calendo, Gennaro, Madzo, Jozef, Jelinek, Jaroslav, Issa, Jean-Pierre J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933260/
https://www.ncbi.nlm.nih.gov/pubmed/36797759
http://dx.doi.org/10.1186/s13059-023-02866-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933260/
https://www.ncbi.nlm.nih.gov/pubmed/36797759
http://dx.doi.org/10.1186/s13059-023-02866-4

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