Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms

BACKGROUND: Osteoporosis is highly polygenic and heritable, with heritability ranging from 50 to 80%; most inherited susceptibility is associated with the cumulative effect of many common genetic variants. However, existing genetic risk scores (GRS) only provide a few percent predictive power for os...

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Detalles Bibliográficos
Autores principales: Wu, Qing, Jung, Jongyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933300/
https://www.ncbi.nlm.nih.gov/pubmed/36797788
http://dx.doi.org/10.1186/s12967-023-03974-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933300/
https://www.ncbi.nlm.nih.gov/pubmed/36797788
http://dx.doi.org/10.1186/s12967-023-03974-2

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