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Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms

BACKGROUND: Osteoporosis is highly polygenic and heritable, with heritability ranging from 50 to 80%; most inherited susceptibility is associated with the cumulative effect of many common genetic variants. However, existing genetic risk scores (GRS) only provide a few percent predictive power for os...

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Detalles Bibliográficos
Autores principales:	Wu, Qing, Jung, Jongyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933300/ https://www.ncbi.nlm.nih.gov/pubmed/36797788 http://dx.doi.org/10.1186/s12967-023-03974-2

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