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T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections

PURPOSE OF THE RESEARCH: We proposed T-cell lymphocytopenia as a strategic predictor of serious coronavirus and influenza infections. Our preeminent goal was to determine whether a degree of T-cell lymphopenia would identify a distinct threshold cell count to differentiate between severe and non-sev...

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Autores principales: Putter, Jeffrey S., Seghatchian, Jerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933323/
https://www.ncbi.nlm.nih.gov/pubmed/36989654
http://dx.doi.org/10.1016/j.cyto.2023.156163
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author Putter, Jeffrey S.
Seghatchian, Jerard
author_facet Putter, Jeffrey S.
Seghatchian, Jerard
author_sort Putter, Jeffrey S.
collection PubMed
description PURPOSE OF THE RESEARCH: We proposed T-cell lymphocytopenia as a strategic predictor of serious coronavirus and influenza infections. Our preeminent goal was to determine whether a degree of T-cell lymphopenia would identify a distinct threshold cell count to differentiate between severe and non-severe infections. We codified an Index Severity Score to exploit an association between T-cell cytopenia and the grade of disease activity. PRINCIPAL RESULT: A T-cell count of 560 cells/uL or below signified a trend towards advanced disease. KEY FINDINGS AND CONCLUSIONS: (1.).. The T-cell threshold > 560 cells/uL discriminated 85.7 % specificity of the lesser viral infections and <=560 cells/uL identified 100 % sensitivity of severe infections or death. (2.).. The positive predictive value of this threshold test was 92.9 %. (3.).. T-cell apoptosis and sequestration are two of the primary mechanisms of T-cell lymphodepletion. (4.).. There is potential for the T-cell threshold at <=560 cells/uL to become a standard to differentiate disease severity. (5.).. The T-cell threshold should be tested further against flow cytometry of CD4+, CD8+ counts of individual patients. (6.).. Future research should explore correlations between the T-cell threshold, medical outcomes of treatment, Cytokine Release Syndromes, cytokine levels, inflammatory and coagulation markers.
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spelling pubmed-99333232023-02-16 T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections Putter, Jeffrey S. Seghatchian, Jerard Cytokine Article PURPOSE OF THE RESEARCH: We proposed T-cell lymphocytopenia as a strategic predictor of serious coronavirus and influenza infections. Our preeminent goal was to determine whether a degree of T-cell lymphopenia would identify a distinct threshold cell count to differentiate between severe and non-severe infections. We codified an Index Severity Score to exploit an association between T-cell cytopenia and the grade of disease activity. PRINCIPAL RESULT: A T-cell count of 560 cells/uL or below signified a trend towards advanced disease. KEY FINDINGS AND CONCLUSIONS: (1.).. The T-cell threshold > 560 cells/uL discriminated 85.7 % specificity of the lesser viral infections and <=560 cells/uL identified 100 % sensitivity of severe infections or death. (2.).. The positive predictive value of this threshold test was 92.9 %. (3.).. T-cell apoptosis and sequestration are two of the primary mechanisms of T-cell lymphodepletion. (4.).. There is potential for the T-cell threshold at <=560 cells/uL to become a standard to differentiate disease severity. (5.).. The T-cell threshold should be tested further against flow cytometry of CD4+, CD8+ counts of individual patients. (6.).. Future research should explore correlations between the T-cell threshold, medical outcomes of treatment, Cytokine Release Syndromes, cytokine levels, inflammatory and coagulation markers. Elsevier Ltd. 2023-05 2023-02-16 /pmc/articles/PMC9933323/ /pubmed/36989654 http://dx.doi.org/10.1016/j.cyto.2023.156163 Text en © 2023 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Putter, Jeffrey S.
Seghatchian, Jerard
T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections
title T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections
title_full T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections
title_fullStr T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections
title_full_unstemmed T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections
title_short T-cell lymphocytopenia: An omnipresent predictor of morbidity and mortality in consequence of SARS-CoV disease and influenza A infections
title_sort t-cell lymphocytopenia: an omnipresent predictor of morbidity and mortality in consequence of sars-cov disease and influenza a infections
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933323/
https://www.ncbi.nlm.nih.gov/pubmed/36989654
http://dx.doi.org/10.1016/j.cyto.2023.156163
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