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Contraction of human brain vascular pericytes in response to islet amyloid polypeptide is reversed by pramlintide
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where i...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933335/ https://www.ncbi.nlm.nih.gov/pubmed/36793056 http://dx.doi.org/10.1186/s13041-023-01013-1 |