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NK cells are never alone: crosstalk and communication in tumour microenvironments
Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) cell-based immunotherapy, which becomes a key factor triggering tumour progression. Understanding the crosstalk between NK cell...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933398/ https://www.ncbi.nlm.nih.gov/pubmed/36797782 http://dx.doi.org/10.1186/s12943-023-01737-7 |
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author | Zhou, Yongqiang Cheng, Lu Liu, Lu Li, Xun |
author_facet | Zhou, Yongqiang Cheng, Lu Liu, Lu Li, Xun |
author_sort | Zhou, Yongqiang |
collection | PubMed |
description | Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) cell-based immunotherapy, which becomes a key factor triggering tumour progression. Understanding the crosstalk between NK cells and the TME provides new insights for optimising NK cell-based immunotherapy. Here, we present new advances in direct or indirect crosstalk between NK cells and 9 specialised TMEs, including immune, metabolic, innervated niche, mechanical, and microbial microenvironments, summarise TME-mediated mechanisms of NK cell function inhibition, and highlight potential targeted therapies for NK-TME crosstalk. Importantly, we discuss novel strategies to overcome the inhibitory TME and provide an attractive outlook for the future. |
format | Online Article Text |
id | pubmed-9933398 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-99333982023-02-17 NK cells are never alone: crosstalk and communication in tumour microenvironments Zhou, Yongqiang Cheng, Lu Liu, Lu Li, Xun Mol Cancer Review Immune escape is a hallmark of cancer. The dynamic and heterogeneous tumour microenvironment (TME) causes insufficient infiltration and poor efficacy of natural killer (NK) cell-based immunotherapy, which becomes a key factor triggering tumour progression. Understanding the crosstalk between NK cells and the TME provides new insights for optimising NK cell-based immunotherapy. Here, we present new advances in direct or indirect crosstalk between NK cells and 9 specialised TMEs, including immune, metabolic, innervated niche, mechanical, and microbial microenvironments, summarise TME-mediated mechanisms of NK cell function inhibition, and highlight potential targeted therapies for NK-TME crosstalk. Importantly, we discuss novel strategies to overcome the inhibitory TME and provide an attractive outlook for the future. BioMed Central 2023-02-16 /pmc/articles/PMC9933398/ /pubmed/36797782 http://dx.doi.org/10.1186/s12943-023-01737-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhou, Yongqiang Cheng, Lu Liu, Lu Li, Xun NK cells are never alone: crosstalk and communication in tumour microenvironments |
title | NK cells are never alone: crosstalk and communication in tumour microenvironments |
title_full | NK cells are never alone: crosstalk and communication in tumour microenvironments |
title_fullStr | NK cells are never alone: crosstalk and communication in tumour microenvironments |
title_full_unstemmed | NK cells are never alone: crosstalk and communication in tumour microenvironments |
title_short | NK cells are never alone: crosstalk and communication in tumour microenvironments |
title_sort | nk cells are never alone: crosstalk and communication in tumour microenvironments |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933398/ https://www.ncbi.nlm.nih.gov/pubmed/36797782 http://dx.doi.org/10.1186/s12943-023-01737-7 |
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