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Hemophagocytic Lymphohistiocytosis and Clostridium difficile Infection: A Diagnostic Dilemma
Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition that often goes underdiagnosed because of broad and non-specific symptomatology, usually consisting of fever, hepatosplenomegaly, and multiorgan failure. This disorder can be driven by genetic components (primary) or acquired (...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933418/ https://www.ncbi.nlm.nih.gov/pubmed/36819301 http://dx.doi.org/10.7759/cureus.33865 |
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author | Boldig, Kimberly Kiamos, Amy Agrawal, Avni Reddy, Pramod |
author_facet | Boldig, Kimberly Kiamos, Amy Agrawal, Avni Reddy, Pramod |
author_sort | Boldig, Kimberly |
collection | PubMed |
description | Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition that often goes underdiagnosed because of broad and non-specific symptomatology, usually consisting of fever, hepatosplenomegaly, and multiorgan failure. This disorder can be driven by genetic components (primary) or acquired (secondary) causes related to infectious, autoimmune, or malignant processes. HLH pathogenesis derives from overactive and dysregulated immune system responses. This disorder often goes misdiagnosed because of similar clinical and laboratory findings to septicemia. Cases of HLH most commonly coexist with Epstein-Barr virus (EBV). Clostridium difficile (C. difficile) infection causing HLH has also rarely been described in the literature. A firm knowledge of HLH association with clostridial infection is essential to recognize. A presumed diagnosis of HLH in a decompensating patient may prompt the initiation of appropriate treatment earlier and improve clinical outcomes. We discuss the diagnostic and management difficulties associated with these concurrent conditions. |
format | Online Article Text |
id | pubmed-9933418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-99334182023-02-17 Hemophagocytic Lymphohistiocytosis and Clostridium difficile Infection: A Diagnostic Dilemma Boldig, Kimberly Kiamos, Amy Agrawal, Avni Reddy, Pramod Cureus Infectious Disease Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition that often goes underdiagnosed because of broad and non-specific symptomatology, usually consisting of fever, hepatosplenomegaly, and multiorgan failure. This disorder can be driven by genetic components (primary) or acquired (secondary) causes related to infectious, autoimmune, or malignant processes. HLH pathogenesis derives from overactive and dysregulated immune system responses. This disorder often goes misdiagnosed because of similar clinical and laboratory findings to septicemia. Cases of HLH most commonly coexist with Epstein-Barr virus (EBV). Clostridium difficile (C. difficile) infection causing HLH has also rarely been described in the literature. A firm knowledge of HLH association with clostridial infection is essential to recognize. A presumed diagnosis of HLH in a decompensating patient may prompt the initiation of appropriate treatment earlier and improve clinical outcomes. We discuss the diagnostic and management difficulties associated with these concurrent conditions. Cureus 2023-01-17 /pmc/articles/PMC9933418/ /pubmed/36819301 http://dx.doi.org/10.7759/cureus.33865 Text en Copyright © 2023, Boldig et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Infectious Disease Boldig, Kimberly Kiamos, Amy Agrawal, Avni Reddy, Pramod Hemophagocytic Lymphohistiocytosis and Clostridium difficile Infection: A Diagnostic Dilemma |
title | Hemophagocytic Lymphohistiocytosis and Clostridium difficile Infection: A Diagnostic Dilemma |
title_full | Hemophagocytic Lymphohistiocytosis and Clostridium difficile Infection: A Diagnostic Dilemma |
title_fullStr | Hemophagocytic Lymphohistiocytosis and Clostridium difficile Infection: A Diagnostic Dilemma |
title_full_unstemmed | Hemophagocytic Lymphohistiocytosis and Clostridium difficile Infection: A Diagnostic Dilemma |
title_short | Hemophagocytic Lymphohistiocytosis and Clostridium difficile Infection: A Diagnostic Dilemma |
title_sort | hemophagocytic lymphohistiocytosis and clostridium difficile infection: a diagnostic dilemma |
topic | Infectious Disease |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933418/ https://www.ncbi.nlm.nih.gov/pubmed/36819301 http://dx.doi.org/10.7759/cureus.33865 |
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