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Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions

[Image: see text] Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with three basic organic counterions, that is, 4-aminopyridine (4AP...

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Autores principales: Huang, Shan, Venables, Dean S., Lawrence, Simon E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933440/
https://www.ncbi.nlm.nih.gov/pubmed/36817751
http://dx.doi.org/10.1021/acs.cgd.2c00722
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author Huang, Shan
Venables, Dean S.
Lawrence, Simon E.
author_facet Huang, Shan
Venables, Dean S.
Lawrence, Simon E.
author_sort Huang, Shan
collection PubMed
description [Image: see text] Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with three basic organic counterions, that is, 4-aminopyridine (4AP), 4-dimethylaminopyridine (4DMP), and piperazine (PPZ), were prepared by both slurrying and slow evaporation. These salts were characterized by single-crystal and powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectroscopy. All six salts, especially MEL-4DMP and MEL-4AP, showed a significantly improved apparent solubility and dissolution rate in sodium phosphate solution compared with the pure APIs. Notably, PRM-4AP and PRM-4DMP salts exhibited enhanced fluorescence, and the PRM-PPZ salt showed weaker fluorescence compared with that of pure PRM due to different luminescence mechanisms.
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spelling pubmed-99334402023-02-17 Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions Huang, Shan Venables, Dean S. Lawrence, Simon E. Cryst Growth Des [Image: see text] Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with three basic organic counterions, that is, 4-aminopyridine (4AP), 4-dimethylaminopyridine (4DMP), and piperazine (PPZ), were prepared by both slurrying and slow evaporation. These salts were characterized by single-crystal and powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectroscopy. All six salts, especially MEL-4DMP and MEL-4AP, showed a significantly improved apparent solubility and dissolution rate in sodium phosphate solution compared with the pure APIs. Notably, PRM-4AP and PRM-4DMP salts exhibited enhanced fluorescence, and the PRM-PPZ salt showed weaker fluorescence compared with that of pure PRM due to different luminescence mechanisms. American Chemical Society 2022-10-21 /pmc/articles/PMC9933440/ /pubmed/36817751 http://dx.doi.org/10.1021/acs.cgd.2c00722 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Huang, Shan
Venables, Dean S.
Lawrence, Simon E.
Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
title Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
title_full Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
title_fullStr Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
title_full_unstemmed Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
title_short Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
title_sort pharmaceutical salts of piroxicam and meloxicam with organic counterions
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933440/
https://www.ncbi.nlm.nih.gov/pubmed/36817751
http://dx.doi.org/10.1021/acs.cgd.2c00722
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