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Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions
[Image: see text] Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with three basic organic counterions, that is, 4-aminopyridine (4AP...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933440/ https://www.ncbi.nlm.nih.gov/pubmed/36817751 http://dx.doi.org/10.1021/acs.cgd.2c00722 |
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author | Huang, Shan Venables, Dean S. Lawrence, Simon E. |
author_facet | Huang, Shan Venables, Dean S. Lawrence, Simon E. |
author_sort | Huang, Shan |
collection | PubMed |
description | [Image: see text] Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with three basic organic counterions, that is, 4-aminopyridine (4AP), 4-dimethylaminopyridine (4DMP), and piperazine (PPZ), were prepared by both slurrying and slow evaporation. These salts were characterized by single-crystal and powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectroscopy. All six salts, especially MEL-4DMP and MEL-4AP, showed a significantly improved apparent solubility and dissolution rate in sodium phosphate solution compared with the pure APIs. Notably, PRM-4AP and PRM-4DMP salts exhibited enhanced fluorescence, and the PRM-PPZ salt showed weaker fluorescence compared with that of pure PRM due to different luminescence mechanisms. |
format | Online Article Text |
id | pubmed-9933440 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Chemical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-99334402023-02-17 Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions Huang, Shan Venables, Dean S. Lawrence, Simon E. Cryst Growth Des [Image: see text] Piroxicam (PRM) and meloxicam (MEL) are two nonsteroidal anti-inflammatory drugs, belonging to the Biopharmaceutics Classification System Class II drugs. In this study, six novel pharmaceutical salts of PRM and MEL with three basic organic counterions, that is, 4-aminopyridine (4AP), 4-dimethylaminopyridine (4DMP), and piperazine (PPZ), were prepared by both slurrying and slow evaporation. These salts were characterized by single-crystal and powder X-ray diffraction, thermal analysis, and Fourier transform infrared spectroscopy. All six salts, especially MEL-4DMP and MEL-4AP, showed a significantly improved apparent solubility and dissolution rate in sodium phosphate solution compared with the pure APIs. Notably, PRM-4AP and PRM-4DMP salts exhibited enhanced fluorescence, and the PRM-PPZ salt showed weaker fluorescence compared with that of pure PRM due to different luminescence mechanisms. American Chemical Society 2022-10-21 /pmc/articles/PMC9933440/ /pubmed/36817751 http://dx.doi.org/10.1021/acs.cgd.2c00722 Text en © 2022 American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Huang, Shan Venables, Dean S. Lawrence, Simon E. Pharmaceutical Salts of Piroxicam and Meloxicam with Organic Counterions |
title | Pharmaceutical Salts
of Piroxicam and Meloxicam with
Organic Counterions |
title_full | Pharmaceutical Salts
of Piroxicam and Meloxicam with
Organic Counterions |
title_fullStr | Pharmaceutical Salts
of Piroxicam and Meloxicam with
Organic Counterions |
title_full_unstemmed | Pharmaceutical Salts
of Piroxicam and Meloxicam with
Organic Counterions |
title_short | Pharmaceutical Salts
of Piroxicam and Meloxicam with
Organic Counterions |
title_sort | pharmaceutical salts
of piroxicam and meloxicam with
organic counterions |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933440/ https://www.ncbi.nlm.nih.gov/pubmed/36817751 http://dx.doi.org/10.1021/acs.cgd.2c00722 |
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