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Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection
The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro. Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil and avibactam ARX-1796 showed efficacy in a mouse mode...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933631/ https://www.ncbi.nlm.nih.gov/pubmed/36688684 http://dx.doi.org/10.1128/aac.01459-22 |
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| author | Negatu, Dereje A. González del Río, Rubén Cacho-Izquierdo, Mónica Barros-Aguirre, David Lelievre, Joël Rullas, Joaquín Casado, Patricia Ganapathy, Uday S. Zimmerman, Matthew D. Gengenbacher, Martin Dartois, Véronique Dick, Thomas |
| author_facet | Negatu, Dereje A. González del Río, Rubén Cacho-Izquierdo, Mónica Barros-Aguirre, David Lelievre, Joël Rullas, Joaquín Casado, Patricia Ganapathy, Uday S. Zimmerman, Matthew D. Gengenbacher, Martin Dartois, Véronique Dick, Thomas |
| author_sort | Negatu, Dereje A. |
| collection | PubMed |
| description | The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro. Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil and avibactam ARX-1796 showed efficacy in a mouse model of M. abscessus lung infection. The results suggest that tebipenem-avibactam presents an attractive oral drug candidate pair for the treatment of M. abscessus pulmonary disease and could inform the design of clinical trials. |
| format | Online Article Text |
| id | pubmed-9933631 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | American Society for Microbiology |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99336312023-02-17 Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection Negatu, Dereje A. González del Río, Rubén Cacho-Izquierdo, Mónica Barros-Aguirre, David Lelievre, Joël Rullas, Joaquín Casado, Patricia Ganapathy, Uday S. Zimmerman, Matthew D. Gengenbacher, Martin Dartois, Véronique Dick, Thomas Antimicrob Agents Chemother Experimental Therapeutics The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro. Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil and avibactam ARX-1796 showed efficacy in a mouse model of M. abscessus lung infection. The results suggest that tebipenem-avibactam presents an attractive oral drug candidate pair for the treatment of M. abscessus pulmonary disease and could inform the design of clinical trials. American Society for Microbiology 2023-01-23 /pmc/articles/PMC9933631/ /pubmed/36688684 http://dx.doi.org/10.1128/aac.01459-22 Text en Copyright © 2023 Negatu et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
| spellingShingle | Experimental Therapeutics Negatu, Dereje A. González del Río, Rubén Cacho-Izquierdo, Mónica Barros-Aguirre, David Lelievre, Joël Rullas, Joaquín Casado, Patricia Ganapathy, Uday S. Zimmerman, Matthew D. Gengenbacher, Martin Dartois, Véronique Dick, Thomas Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection |
| title | Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection |
| title_full | Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection |
| title_fullStr | Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection |
| title_full_unstemmed | Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection |
| title_short | Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection |
| title_sort | activity of oral tebipenem-avibactam in a mouse model of mycobacterium abscessus lung infection |
| topic | Experimental Therapeutics |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933631/ https://www.ncbi.nlm.nih.gov/pubmed/36688684 http://dx.doi.org/10.1128/aac.01459-22 |
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