ATOH8 binds SMAD3 to induce cellular senescence and prevent Ras-driven malignant transformation

The process of oncogene-induced senescence (OIS) and the conversion between OIS and malignant transformation during carcinogenesis is poorly understood. Here, we show that following overactivation of oncogene Ras in lung epithelial cells, high-level transforming growth factor β1 (TGF-β1)–activated S...

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Detalles Bibliográficos
Autores principales: Liu, Ximeng, Li, Xu, Wang, Shuang, Liu, Qin, Feng, Xianming, Wang, Wenting, Huang, Zhangduo, Huang, Yongbo, Wu, Jueheng, Cai, Muyan, Cai, Xiuyu, Xu, Xiaonan, Cai, Junchao, Li, Mengfeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934021/
https://www.ncbi.nlm.nih.gov/pubmed/36626550
http://dx.doi.org/10.1073/pnas.2208927120

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