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How acidic amino acid residues facilitate DNA target site selection

Despite the negative charge of the DNA backbone, acidic residues (Asp/Glu) commonly participate in the base readout, with a strong preference for cytosine. In fact, in the solved DNA/protein structures, cytosine is recognized almost exclusively by Asp/Glu through a direct hydrogen bond, while at the...

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Detalles Bibliográficos
Autores principales:	Hossain, Kazi Amirul, Kogut, Mateusz, Słabońska, Joanna, Sappati, Subrahmanyam, Wieczór, Miłosz, Czub, Jacek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934023/ https://www.ncbi.nlm.nih.gov/pubmed/36634135 http://dx.doi.org/10.1073/pnas.2212501120

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