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CHRONIC KIDNEY DISEASE IN RURAL POPULATION

The aims of the study were to provide data on chronic kidney disease (CKD) prevalence in rural population and to analyze the association with cardiovascular risk factors and aging. A random sample of 2193 farmers (1333 female (F) and 860 male (M), mean age 50.61±17.12) were enrolled. Questionnaire a...

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Autores principales: Domislović, Marija, Domislović, Viktor, Stevanović, Ranko, Fuček, Mirjana, Dika, Živka, Karanović, Sandra, Kos, Jelena, Jelaković, Ana, Premužić, Vedran, Leko, Ninoslav, Josipović, Josipa, Brzić, Ivan, Željković Vrkić, Tajana, Capak, Krunoslav, Jelaković, Bojan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934033/
https://www.ncbi.nlm.nih.gov/pubmed/36818921
http://dx.doi.org/10.20471/acc.2022.61.02.09
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author Domislović, Marija
Domislović, Viktor
Stevanović, Ranko
Fuček, Mirjana
Dika, Živka
Karanović, Sandra
Kos, Jelena
Jelaković, Ana
Premužić, Vedran
Leko, Ninoslav
Josipović, Josipa
Brzić, Ivan
Željković Vrkić, Tajana
Capak, Krunoslav
Jelaković, Bojan
author_facet Domislović, Marija
Domislović, Viktor
Stevanović, Ranko
Fuček, Mirjana
Dika, Živka
Karanović, Sandra
Kos, Jelena
Jelaković, Ana
Premužić, Vedran
Leko, Ninoslav
Josipović, Josipa
Brzić, Ivan
Željković Vrkić, Tajana
Capak, Krunoslav
Jelaković, Bojan
author_sort Domislović, Marija
collection PubMed
description The aims of the study were to provide data on chronic kidney disease (CKD) prevalence in rural population and to analyze the association with cardiovascular risk factors and aging. A random sample of 2193 farmers (1333 female (F) and 860 male (M), mean age 50.61±17.12) were enrolled. Questionnaire and clinical examination were conducted. Participants provided a spot urine and fasting blood sample. Estimated glomerular filtration rate (eGFR) was estimated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Subjects were classified according to the KDIGO guidelines. The overall prevalence of CKD (eGFR <60 mL/min/1.73 m(2)) was 8.83% (F vs. M 9.9% vs. 6.3%; p<0.001). Albuminuria (albumin-to-creatinine ratio >30 mg/g) was found in 8.45% (F vs. M p>0.05). Sharp increase in CKD prevalence was found to begin after the sixth decade (29.44% in subjects older than 65 years; F vs. M 30.9% vs. 26.8%; p<0.01). The strongest predictor factors for CKD were age >65 years (OR 22.12), hypertension (OR 6.53), albuminuria (OR 5.71), fasting blood glucose >7 mmol/L (OR 5.49), diabetes (OR 3.07), abdominal obesity (OR 2.05) and non-smoking (OR 0.41). In multivariate analysis, age (OR 1.13), female gender (OR 0.60) and diabetes (OR 1.75) were the independent predictor factors for CKD. In conclusion, CKD prevalence is high in rural population, being higher in women than in men. In both genders, eGFR significantly decreased with aging. Aging is a significant independent predictor of CKD.
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spelling pubmed-99340332023-02-17 CHRONIC KIDNEY DISEASE IN RURAL POPULATION Domislović, Marija Domislović, Viktor Stevanović, Ranko Fuček, Mirjana Dika, Živka Karanović, Sandra Kos, Jelena Jelaković, Ana Premužić, Vedran Leko, Ninoslav Josipović, Josipa Brzić, Ivan Željković Vrkić, Tajana Capak, Krunoslav Jelaković, Bojan Acta Clin Croat Original Scientific Papers The aims of the study were to provide data on chronic kidney disease (CKD) prevalence in rural population and to analyze the association with cardiovascular risk factors and aging. A random sample of 2193 farmers (1333 female (F) and 860 male (M), mean age 50.61±17.12) were enrolled. Questionnaire and clinical examination were conducted. Participants provided a spot urine and fasting blood sample. Estimated glomerular filtration rate (eGFR) was estimated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. Subjects were classified according to the KDIGO guidelines. The overall prevalence of CKD (eGFR <60 mL/min/1.73 m(2)) was 8.83% (F vs. M 9.9% vs. 6.3%; p<0.001). Albuminuria (albumin-to-creatinine ratio >30 mg/g) was found in 8.45% (F vs. M p>0.05). Sharp increase in CKD prevalence was found to begin after the sixth decade (29.44% in subjects older than 65 years; F vs. M 30.9% vs. 26.8%; p<0.01). The strongest predictor factors for CKD were age >65 years (OR 22.12), hypertension (OR 6.53), albuminuria (OR 5.71), fasting blood glucose >7 mmol/L (OR 5.49), diabetes (OR 3.07), abdominal obesity (OR 2.05) and non-smoking (OR 0.41). In multivariate analysis, age (OR 1.13), female gender (OR 0.60) and diabetes (OR 1.75) were the independent predictor factors for CKD. In conclusion, CKD prevalence is high in rural population, being higher in women than in men. In both genders, eGFR significantly decreased with aging. Aging is a significant independent predictor of CKD. Sestre Milosrdnice University Hospital and Institute of Clinical Medical Research, Vinogradska cesta c. 29 Zagreb 2022-08 /pmc/articles/PMC9934033/ /pubmed/36818921 http://dx.doi.org/10.20471/acc.2022.61.02.09 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (CC BY-NC-ND) 4.0 License.
spellingShingle Original Scientific Papers
Domislović, Marija
Domislović, Viktor
Stevanović, Ranko
Fuček, Mirjana
Dika, Živka
Karanović, Sandra
Kos, Jelena
Jelaković, Ana
Premužić, Vedran
Leko, Ninoslav
Josipović, Josipa
Brzić, Ivan
Željković Vrkić, Tajana
Capak, Krunoslav
Jelaković, Bojan
CHRONIC KIDNEY DISEASE IN RURAL POPULATION
title CHRONIC KIDNEY DISEASE IN RURAL POPULATION
title_full CHRONIC KIDNEY DISEASE IN RURAL POPULATION
title_fullStr CHRONIC KIDNEY DISEASE IN RURAL POPULATION
title_full_unstemmed CHRONIC KIDNEY DISEASE IN RURAL POPULATION
title_short CHRONIC KIDNEY DISEASE IN RURAL POPULATION
title_sort chronic kidney disease in rural population
topic Original Scientific Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934033/
https://www.ncbi.nlm.nih.gov/pubmed/36818921
http://dx.doi.org/10.20471/acc.2022.61.02.09
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