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CITED2 is a conserved regulator of the uterine–placental interface

Establishment of the hemochorial uterine–placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly understood. We examined the involvement of CBP/p300-intera...

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Autores principales: Kuna, Marija, Dhakal, Pramod, Iqbal, Khursheed, Dominguez, Esteban M., Kent, Lindsey N., Muto, Masanaga, Moreno-Irusta, Ayelen, Kozai, Keisuke, Varberg, Kaela M., Okae, Hiroaki, Arima, Takahiro, Sucov, Henry M., Soares, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934066/
https://www.ncbi.nlm.nih.gov/pubmed/36626551
http://dx.doi.org/10.1073/pnas.2213622120
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author Kuna, Marija
Dhakal, Pramod
Iqbal, Khursheed
Dominguez, Esteban M.
Kent, Lindsey N.
Muto, Masanaga
Moreno-Irusta, Ayelen
Kozai, Keisuke
Varberg, Kaela M.
Okae, Hiroaki
Arima, Takahiro
Sucov, Henry M.
Soares, Michael J.
author_facet Kuna, Marija
Dhakal, Pramod
Iqbal, Khursheed
Dominguez, Esteban M.
Kent, Lindsey N.
Muto, Masanaga
Moreno-Irusta, Ayelen
Kozai, Keisuke
Varberg, Kaela M.
Okae, Hiroaki
Arima, Takahiro
Sucov, Henry M.
Soares, Michael J.
author_sort Kuna, Marija
collection PubMed
description Establishment of the hemochorial uterine–placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly understood. We examined the involvement of CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) in rat and human trophoblast cell development. The rat and human exhibit deep hemochorial placentation. CITED2 was distinctively expressed in the junctional zone (JZ) and invasive trophoblast cells of the rat. Homozygous Cited2 gene deletion resulted in placental and fetal growth restriction. Small Cited2 null placentas were characterized by disruptions in the JZ, delays in intrauterine trophoblast cell invasion, and compromised plasticity. In the human placentation site, CITED2 was uniquely expressed in the extravillous trophoblast (EVT) cell column and importantly contributed to the development of the EVT cell lineage. We conclude that CITED2 is a conserved regulator of deep hemochorial placentation.
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spelling pubmed-99340662023-07-10 CITED2 is a conserved regulator of the uterine–placental interface Kuna, Marija Dhakal, Pramod Iqbal, Khursheed Dominguez, Esteban M. Kent, Lindsey N. Muto, Masanaga Moreno-Irusta, Ayelen Kozai, Keisuke Varberg, Kaela M. Okae, Hiroaki Arima, Takahiro Sucov, Henry M. Soares, Michael J. Proc Natl Acad Sci U S A Biological Sciences Establishment of the hemochorial uterine–placental interface requires exodus of trophoblast cells from the placenta and their transformative actions on the uterus, which represent processes critical for a successful pregnancy, but are poorly understood. We examined the involvement of CBP/p300-interacting transactivator with glutamic acid/aspartic acid-rich carboxyl-terminal domain 2 (CITED2) in rat and human trophoblast cell development. The rat and human exhibit deep hemochorial placentation. CITED2 was distinctively expressed in the junctional zone (JZ) and invasive trophoblast cells of the rat. Homozygous Cited2 gene deletion resulted in placental and fetal growth restriction. Small Cited2 null placentas were characterized by disruptions in the JZ, delays in intrauterine trophoblast cell invasion, and compromised plasticity. In the human placentation site, CITED2 was uniquely expressed in the extravillous trophoblast (EVT) cell column and importantly contributed to the development of the EVT cell lineage. We conclude that CITED2 is a conserved regulator of deep hemochorial placentation. National Academy of Sciences 2023-01-10 2023-01-17 /pmc/articles/PMC9934066/ /pubmed/36626551 http://dx.doi.org/10.1073/pnas.2213622120 Text en Copyright © 2023 the Author(s). Published by PNAS. https://creativecommons.org/licenses/by-nc-nd/4.0/This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Biological Sciences
Kuna, Marija
Dhakal, Pramod
Iqbal, Khursheed
Dominguez, Esteban M.
Kent, Lindsey N.
Muto, Masanaga
Moreno-Irusta, Ayelen
Kozai, Keisuke
Varberg, Kaela M.
Okae, Hiroaki
Arima, Takahiro
Sucov, Henry M.
Soares, Michael J.
CITED2 is a conserved regulator of the uterine–placental interface
title CITED2 is a conserved regulator of the uterine–placental interface
title_full CITED2 is a conserved regulator of the uterine–placental interface
title_fullStr CITED2 is a conserved regulator of the uterine–placental interface
title_full_unstemmed CITED2 is a conserved regulator of the uterine–placental interface
title_short CITED2 is a conserved regulator of the uterine–placental interface
title_sort cited2 is a conserved regulator of the uterine–placental interface
topic Biological Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934066/
https://www.ncbi.nlm.nih.gov/pubmed/36626551
http://dx.doi.org/10.1073/pnas.2213622120
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