The mechanism of thia-Michael addition catalyzed by LanC enzymes

In both eukarya and bacteria, the addition of Cys to dehydroalanine (Dha) and dehydrobutyrine (Dhb) occurs in various biological processes. In bacteria, intramolecular thia-Michael addition catalyzed by lanthipeptide cyclases (LanC) proteins or protein domains gives rise to a class of natural produc...

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Detalles Bibliográficos
Autores principales: Ongpipattanakul, Chayanid, Liu, Shi, Luo, Youran, Nair, Satish K., van der Donk, Wilfred A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934072/
https://www.ncbi.nlm.nih.gov/pubmed/36634136
http://dx.doi.org/10.1073/pnas.2217523120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934072/
https://www.ncbi.nlm.nih.gov/pubmed/36634136
http://dx.doi.org/10.1073/pnas.2217523120

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