Cargando…

KCNH2 encodes a nuclear-targeted polypeptide that mediates hERG1 channel gating and expression

KCNH2 encodes hERG1, the voltage-gated potassium channel that conducts the rapid delayed rectifier potassium current (I(Kr)) in human cardiac tissue. hERG1 is one of the first channels expressed during early cardiac development, and its dysfunction is associated with intrauterine fetal death, sudden...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jain, Abhilasha, Stack, Olivia, Ghodrati, Saba, Sanchez-Conde, Francisco G., Ukachukwu, Chiamaka U., Salwi, Shreya, Jimenez-Vazquez, Eric N., Jones, David K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934303/ https://www.ncbi.nlm.nih.gov/pubmed/36626562 http://dx.doi.org/10.1073/pnas.2214700120

Ejemplares similares

hERG1 channel subunit composition mediates proton inhibition of rapid delayed rectifier potassium current (I(Kr)) in cardiomyocytes derived from hiPSCs
por: Ukachukwu, Chiamaka U., et al.
Publicado: (2022)

A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity
por: Oliveira‐Mendes, Barbara, et al.
Publicado: (2021)

Gating and regulation of KCNH (ERG, EAG, and ELK) channels by intracellular domains
por: Codding, Sara J., et al.
Publicado: (2020)

Common variants in the hERG (KCNH2) voltage-gated potassium channel are associated with altered fasting and glucose-stimulated plasma incretin and glucagon responses
por: Engelbrechtsen, Line, et al.
Publicado: (2018)

Voltage-Dependent Gating of hERG Potassium Channels
por: Cheng, Yen May, et al.
Publicado: (2012)

hERG1a N-terminal eag domain–containing polypeptides regulate homomeric hERG1b and heteromeric hERG1a/hERG1b channels: A possible mechanism for long QT syndrome
por: Trudeau, Matthew C., et al.
Publicado: (2011)

Gating Charges in the Activation and Inactivation Processes of the hERG Channel
por: Zhang, Mei, et al.
Publicado: (2004)

Saxitoxin Is a Gating Modifier of hERG K(+) Channels
por: Wang, Jixin, et al.
Publicado: (2003)

Modification of hERG1 channel gating by Cd(2+)
por: Abbruzzese, Jennifer, et al.
Publicado: (2010)

Aborted Cardiac Arrest in LQT2 Related to Novel KCNH2 (hERG) Variant Identified in One Lithuanian Family
por: Bileišienė, Neringa, et al.
Publicado: (2021)

hERG Gating Microdomains Defined by S6 Mutagenesis and Molecular Modeling
por: Wynia-Smith, Sarah L., et al.
Publicado: (2008)

Hysteretic hERG channel gating current recorded at physiological temperature
por: Jones, David K.
Publicado: (2022)

The electric heart of hERG
por: Islas, León D.
Publicado: (2013)

An Update on the Structure of hERG
por: Butler, Andrew, et al.
Publicado: (2020)

Long QT Syndrome Type 2: Emerging Strategies for Correcting Class 2 KCNH2 (hERG) Mutations and Identifying New Patients
por: Ono, Makoto, et al.
Publicado: (2020)

Stoichiometry of altered hERG1 channel gating by small molecule activators
por: Wu, Wei, et al.
Publicado: (2014)

Gating charge movement precedes ionic current activation in hERG channels
por: Goodchild, Samuel J, et al.
Publicado: (2014)

hERG potassium channel gating is mediated by N- and C-terminal region interactions
por: Gustina, Ahleah S., et al.
Publicado: (2011)

Voltage Sensor Gating Charge Transfer in a hERG Potassium Channel Model
por: Colenso, Charlotte K., et al.
Publicado: (2014)

The N-linker region of hERG1a upregulates hERG1b potassium channels
por: Johnson, Ashley A., et al.
Publicado: (2022)

Electrophysiological characterization of the modified hERG(T) potassium channel used to obtain the first cryo‐EM hERG structure
por: Zhang, Yihong, et al.
Publicado: (2020)

The eag domain regulates hERG channel inactivation gating via a direct interaction
por: Gustina, Ahleah S., et al.
Publicado: (2013)

Mechanism of hERG inhibition by gating-modifier toxin, APETx1, deduced by functional characterization
por: Matsumura, Kazuki, et al.
Publicado: (2021)

Molecular Insights Into the Gating Kinetics of the Cardiac hERG Channel, Illuminated by Structure and Molecular Dynamics
por: Zequn, Zheng, et al.
Publicado: (2021)

An Insight into the Potassium Currents of hERG and Their Simulation
por: Guidelli, Rolando
Publicado: (2023)

Stereoselective Blockage of Quinidine and Quinine in the hERG Channel and the Effect of Their Rescue Potency on Drug-Induced hERG Trafficking Defect
por: Yan, Meng, et al.
Publicado: (2016)

Components of gating charge movement and S4 voltage-sensor exposure during activation of hERG channels
por: Wang, Zhuren, et al.
Publicado: (2013)

Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study
por: Perissinotti, Laura L., et al.
Publicado: (2018)

The Interaction between hERG1 and β1 Integrins Modulates hERG1 Current in Different Pathological Cell Models
por: Chioccioli Altadonna, Ginevra, et al.
Publicado: (2022)

Na(+) Permeation and Block of hERG Potassium Channels
por: Gang, Hongying, et al.
Publicado: (2006)

Stereoselective Inhibition of the hERG1 Potassium Channel
por: Grilo, Liliana Sintra, et al.
Publicado: (2010)

Long-Chain Acylcarnitines Regulate the hERG Channel
por: Ferro, Fabio, et al.
Publicado: (2012)

hERG channel function: beyond long QT
por: Babcock, Joseph J, et al.
Publicado: (2013)

Towards a complete structure of the hERG channel
por: Schmidtke, Peter, et al.
Publicado: (2013)

Ion Conduction through the hERG Potassium Channel
por: Ceccarini, Luisa, et al.
Publicado: (2012)

Kv4.3 Modulates the Distribution of hERG
por: Zhao, Xiao-Jing, et al.
Publicado: (2017)

Lipid regulation of hERG1 channel function
por: Miranda, Williams E., et al.
Publicado: (2021)

Trafficking-Deficient G572R-hERG and E637K-hERG Activate Stress and Clearance Pathways in Endoplasmic Reticulum
por: Wang, Ying, et al.
Publicado: (2012)

Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II
por: Ogura, Keiji, et al.
Publicado: (2019)

Mitragynine, an euphoric compound inhibits hERG1a/1b channel current and upregulates the complexation of hERG1a-Hsp90 in HEK293-hERG1a/1b cells
por: Tay, Yea Lu, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_mbsv014ifcsgb9r9bm8i314uqg