Cargando…

A comparison of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) spectacles, atropine, and combined DIMS/atropine

PURPOSE: To evaluate the efficacy of a myopia control spectacle lens (DIMS) at slowing the progression of myopia in a population of European children in comparison with 0.01% atropine and combined DIMS and atropine. METHODS: The study was a non-randomised experimenter-masked prospective controlled o...

Descripción completa

Detalles Bibliográficos
Autores principales: Nucci, Paolo, Lembo, Andrea, Schiavetti, Irene, Shah, Rakhee, Edgar, David Francis, Evans, Bruce John William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934319/
https://www.ncbi.nlm.nih.gov/pubmed/36795775
http://dx.doi.org/10.1371/journal.pone.0281816
_version_ 1784889857900806144
author Nucci, Paolo
Lembo, Andrea
Schiavetti, Irene
Shah, Rakhee
Edgar, David Francis
Evans, Bruce John William
author_facet Nucci, Paolo
Lembo, Andrea
Schiavetti, Irene
Shah, Rakhee
Edgar, David Francis
Evans, Bruce John William
author_sort Nucci, Paolo
collection PubMed
description PURPOSE: To evaluate the efficacy of a myopia control spectacle lens (DIMS) at slowing the progression of myopia in a population of European children in comparison with 0.01% atropine and combined DIMS and atropine. METHODS: The study was a non-randomised experimenter-masked prospective controlled observational study of individuals aged 6–18 years with progressing myopia but no ocular pathology. Participants were allocated, according to patient/parent choice, to receive 0.01% atropine eyedrops, DIMS (Hoya(®) MiyoSmart(®)) spectacles, combined atropine+DIMS or single vision spectacle lenses (control group). The key outcome variables, cycloplegic autorefraction spherical equivalent refraction (SER) and axial length (AL), were measured at baseline and after three, six, and 12 months. RESULTS: Of the 146 participants (mean age 10.3y ±3.2), 53 received atropine, 30 DIMS spectacles, 31 atropine+DIMS, and 32 single vision control spectacles. Generalized linear mixed model analysis revealed for SER, whilst controlling for age and SER at baseline, at each stage all treatment groups had significantly reduced progression compared with the control group (p<0.016). For AL, whilst controlling for baseline age and AL, at 6 and 12 months all treatment groups had significantly less progression than the control group (p<0.005). For SER only, in pairwise comparisons at 12 months the atropine+DIMS group had significantly reduced progression compared with the DIMS only and Atropine only groups (p<0.001). CONCLUSION: In a European population, DIMS and atropine are effective at reducing myopia progression and axial elongation in progressing myopia and are most successful at reducing myopia progression when used in combination.
format Online
Article
Text
id pubmed-9934319
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-99343192023-02-17 A comparison of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) spectacles, atropine, and combined DIMS/atropine Nucci, Paolo Lembo, Andrea Schiavetti, Irene Shah, Rakhee Edgar, David Francis Evans, Bruce John William PLoS One Research Article PURPOSE: To evaluate the efficacy of a myopia control spectacle lens (DIMS) at slowing the progression of myopia in a population of European children in comparison with 0.01% atropine and combined DIMS and atropine. METHODS: The study was a non-randomised experimenter-masked prospective controlled observational study of individuals aged 6–18 years with progressing myopia but no ocular pathology. Participants were allocated, according to patient/parent choice, to receive 0.01% atropine eyedrops, DIMS (Hoya(®) MiyoSmart(®)) spectacles, combined atropine+DIMS or single vision spectacle lenses (control group). The key outcome variables, cycloplegic autorefraction spherical equivalent refraction (SER) and axial length (AL), were measured at baseline and after three, six, and 12 months. RESULTS: Of the 146 participants (mean age 10.3y ±3.2), 53 received atropine, 30 DIMS spectacles, 31 atropine+DIMS, and 32 single vision control spectacles. Generalized linear mixed model analysis revealed for SER, whilst controlling for age and SER at baseline, at each stage all treatment groups had significantly reduced progression compared with the control group (p<0.016). For AL, whilst controlling for baseline age and AL, at 6 and 12 months all treatment groups had significantly less progression than the control group (p<0.005). For SER only, in pairwise comparisons at 12 months the atropine+DIMS group had significantly reduced progression compared with the DIMS only and Atropine only groups (p<0.001). CONCLUSION: In a European population, DIMS and atropine are effective at reducing myopia progression and axial elongation in progressing myopia and are most successful at reducing myopia progression when used in combination. Public Library of Science 2023-02-16 /pmc/articles/PMC9934319/ /pubmed/36795775 http://dx.doi.org/10.1371/journal.pone.0281816 Text en © 2023 Nucci et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Nucci, Paolo
Lembo, Andrea
Schiavetti, Irene
Shah, Rakhee
Edgar, David Francis
Evans, Bruce John William
A comparison of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) spectacles, atropine, and combined DIMS/atropine
title A comparison of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) spectacles, atropine, and combined DIMS/atropine
title_full A comparison of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) spectacles, atropine, and combined DIMS/atropine
title_fullStr A comparison of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) spectacles, atropine, and combined DIMS/atropine
title_full_unstemmed A comparison of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) spectacles, atropine, and combined DIMS/atropine
title_short A comparison of myopia control in European children and adolescents with defocus incorporated multiple segments (DIMS) spectacles, atropine, and combined DIMS/atropine
title_sort comparison of myopia control in european children and adolescents with defocus incorporated multiple segments (dims) spectacles, atropine, and combined dims/atropine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934319/
https://www.ncbi.nlm.nih.gov/pubmed/36795775
http://dx.doi.org/10.1371/journal.pone.0281816
work_keys_str_mv AT nuccipaolo acomparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT lemboandrea acomparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT schiavettiirene acomparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT shahrakhee acomparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT edgardavidfrancis acomparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT evansbrucejohnwilliam acomparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT nuccipaolo comparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT lemboandrea comparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT schiavettiirene comparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT shahrakhee comparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT edgardavidfrancis comparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine
AT evansbrucejohnwilliam comparisonofmyopiacontrolineuropeanchildrenandadolescentswithdefocusincorporatedmultiplesegmentsdimsspectaclesatropineandcombineddimsatropine