OGT controls mammalian cell viability by regulating the proteasome/mTOR/ mitochondrial axis

O-GlcNAc transferase (OGT) modifies serine and threonine residues on nuclear and cytosolic proteins with O-linked N-acetylglucosamine (GlcNAc). OGT is essential for mammalian cell viability, but the underlying mechanisms are still enigmatic. We performed a genome-wide CRISPR–Cas9 screen in mouse emb...

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Detalles Bibliográficos
Autores principales: Li, Xiang, Yue, Xiaojing, Sepulveda, Hugo, Burt, Rajan A., Scott, David A., A. Carr, Steven, A. Myers, Samuel, Rao, Anjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934350/
https://www.ncbi.nlm.nih.gov/pubmed/36626549
http://dx.doi.org/10.1073/pnas.2218332120

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