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Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications

Dendrophthoe falcata (L.f.) Ettingsh. (DF) and Dendrophthoe pentandra (L.) Miq. (DP) have been traditionally used for the treatment of various ailments, such as cancer, ulcers, asthma, paralysis, skin diseases, tuberculosis, and menstrual troubles, in the ethnomedicinal systems of India and Indonesi...

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Autores principales: Kong, Degang, Wang, Lu, Niu, Yingshuo, Cheng, Lingmei, Sang, Bo, Wang, Dan, Tian, Jinli, Zhao, Wei, Liu, Xue, Chen, Yueru, Wang, Fulin, Zhou, Honglei, Jia, Ruyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934394/
https://www.ncbi.nlm.nih.gov/pubmed/36817117
http://dx.doi.org/10.3389/fphar.2023.1096379
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author Kong, Degang
Wang, Lu
Niu, Yingshuo
Cheng, Lingmei
Sang, Bo
Wang, Dan
Tian, Jinli
Zhao, Wei
Liu, Xue
Chen, Yueru
Wang, Fulin
Zhou, Honglei
Jia, Ruyi
author_facet Kong, Degang
Wang, Lu
Niu, Yingshuo
Cheng, Lingmei
Sang, Bo
Wang, Dan
Tian, Jinli
Zhao, Wei
Liu, Xue
Chen, Yueru
Wang, Fulin
Zhou, Honglei
Jia, Ruyi
author_sort Kong, Degang
collection PubMed
description Dendrophthoe falcata (L.f.) Ettingsh. (DF) and Dendrophthoe pentandra (L.) Miq. (DP) have been traditionally used for the treatment of various ailments, such as cancer, ulcers, asthma, paralysis, skin diseases, tuberculosis, and menstrual troubles, in the ethnomedicinal systems of India and Indonesia. Currently, the chemical structures of 46 compounds have been elucidated from DF and DP, including flavonoids, triterpenes, tannins, steroids, open-chain aliphatics, benzyl derivates, and cyclic chain derivatives. In vitro assays have revealed their anti-tumor and anti-microbial activities. In vivo studies have unraveled their pharmacological properties against tumors, depression, fertility disorders, inflammatory responses, and so on. Additionally, their weak toxicity to rats and brine shrimp, as well as their promising applications for pharmaceutical preparations and combined medication, were also revealed. Herein, we not only recapitulated traditional medical uses, phytochemistry, pharmacology, toxicity, and applications of DF and DP but also discussed current research limitations and future perspectives, which are instructive for those interested in them and are committed to advancing parasitic plants to the Frontier of phytomedicine. We highlighted that DF and DP will become promising medical plants rather than being discarded as notorious pests, provided that more and deeper research is undertaken.
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spelling pubmed-99343942023-02-17 Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications Kong, Degang Wang, Lu Niu, Yingshuo Cheng, Lingmei Sang, Bo Wang, Dan Tian, Jinli Zhao, Wei Liu, Xue Chen, Yueru Wang, Fulin Zhou, Honglei Jia, Ruyi Front Pharmacol Pharmacology Dendrophthoe falcata (L.f.) Ettingsh. (DF) and Dendrophthoe pentandra (L.) Miq. (DP) have been traditionally used for the treatment of various ailments, such as cancer, ulcers, asthma, paralysis, skin diseases, tuberculosis, and menstrual troubles, in the ethnomedicinal systems of India and Indonesia. Currently, the chemical structures of 46 compounds have been elucidated from DF and DP, including flavonoids, triterpenes, tannins, steroids, open-chain aliphatics, benzyl derivates, and cyclic chain derivatives. In vitro assays have revealed their anti-tumor and anti-microbial activities. In vivo studies have unraveled their pharmacological properties against tumors, depression, fertility disorders, inflammatory responses, and so on. Additionally, their weak toxicity to rats and brine shrimp, as well as their promising applications for pharmaceutical preparations and combined medication, were also revealed. Herein, we not only recapitulated traditional medical uses, phytochemistry, pharmacology, toxicity, and applications of DF and DP but also discussed current research limitations and future perspectives, which are instructive for those interested in them and are committed to advancing parasitic plants to the Frontier of phytomedicine. We highlighted that DF and DP will become promising medical plants rather than being discarded as notorious pests, provided that more and deeper research is undertaken. Frontiers Media S.A. 2023-02-02 /pmc/articles/PMC9934394/ /pubmed/36817117 http://dx.doi.org/10.3389/fphar.2023.1096379 Text en Copyright © 2023 Kong, Wang, Niu, Cheng, Sang, Wang, Tian, Zhao, Liu, Chen, Wang, Zhou and Jia. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Kong, Degang
Wang, Lu
Niu, Yingshuo
Cheng, Lingmei
Sang, Bo
Wang, Dan
Tian, Jinli
Zhao, Wei
Liu, Xue
Chen, Yueru
Wang, Fulin
Zhou, Honglei
Jia, Ruyi
Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications
title Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications
title_full Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications
title_fullStr Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications
title_full_unstemmed Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications
title_short Dendrophthoe falcata (L.f.) Ettingsh. and Dendrophthoe pentandra (L.) Miq.: A review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications
title_sort dendrophthoe falcata (l.f.) ettingsh. and dendrophthoe pentandra (l.) miq.: a review of traditional medical uses, phytochemistry, pharmacology, toxicity, and applications
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934394/
https://www.ncbi.nlm.nih.gov/pubmed/36817117
http://dx.doi.org/10.3389/fphar.2023.1096379
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