Comprehensive structural characterization of the human AAA+ disaggregase CLPB in the apo- and substrate-bound states reveals a unique mode of action driven by oligomerization

The human AAA+ ATPase CLPB (SKD3) is a protein disaggregase in the mitochondrial intermembrane space (IMS) and functions to promote the solubilization of various mitochondrial proteins. Loss-of-function CLPB mutations are associated with a few human diseases with neutropenia and neurological disorde...

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Detalles Bibliográficos
Autores principales: Wu, Damu, Liu, Yan, Dai, Yuhao, Wang, Guopeng, Lu, Guoliang, Chen, Yan, Li, Ningning, Lin, Jinzhong, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934407/
https://www.ncbi.nlm.nih.gov/pubmed/36745679
http://dx.doi.org/10.1371/journal.pbio.3001987

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