Contraction pressure analysis using optical imaging in normal and MYBPC3-mutated hiPSC-derived cardiomyocytes grown on matrices with tunable stiffness

Current in vivo disease models and analysis methods for cardiac drug development have been insufficient in providing accurate and reliable predictions of drug efficacy and safety. Here, we propose a custom optical flow-based analysis method to quantitatively measure recordings of contracting cardiom...

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Detalles Bibliográficos
Autores principales: Snelders, Matthijs, Koedijk, Iris H., Schirmer, Julia, Mulleners, Otto, van Leeuwen, Juancito, de Wagenaar, Nathalie P., Bartulos, Oscar, Voskamp, Pieter, Braam, Stefan, Guttenberg, Zeno, Danser, A.H. Jan, Majoor-Krakauer, Danielle, Meijering, Erik, van der Pluijm, Ingrid, Essers, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934435/
https://www.ncbi.nlm.nih.gov/pubmed/36824378
http://dx.doi.org/10.1016/j.bbiosy.2022.100068

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