Spinal cord extracts of amyotrophic lateral sclerosis spread TDP-43 pathology in cerebral organoids

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by progressive loss of motor neurons and there is currently no effective therapy. Cytoplasmic mislocalization and aggregation of TAR DNA-binding protein 43 kDa (TDP-43) within the CNS is a pathological hallmark in spora...

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Detalles Bibliográficos
Autores principales: Tamaki, Yoshitaka, Ross, Jay P., Alipour, Paria, Castonguay, Charles-Étienne, Li, Boting, Catoire, Helene, Rochefort, Daniel, Urushitani, Makoto, Takahashi, Ryosuke, Sonnen, Joshua A., Stifani, Stefano, Dion, Patrick A., Rouleau, Guy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934440/
https://www.ncbi.nlm.nih.gov/pubmed/36745687
http://dx.doi.org/10.1371/journal.pgen.1010606

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