APOE4 drives transcriptional heterogeneity and maladaptive immunometabolic responses of astrocytes

Apolipoprotein E4 (APOE4) is the strongest risk allele associated with the development of late onset Alzheimer’s disease (AD). Across the CNS, astrocytes are the predominant expressor of APOE while also being critical mediators of neuroinflammation and cerebral metabolism. APOE4 has been consistentl...

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Detalles Bibliográficos
Autores principales: Lee, Sangderk, Williams, Holden C., Gorman, Amy A., Devanney, Nicholas A., Harrison, Douglas A., Walsh, Adeline E., Goulding, Danielle S., Tuck, Tony, Schwartz, James L., Zajac, Diana J., Macauley, Shannon L., Estus, Steven, Julia, TCW, Johnson, Lance A., Morganti, Josh M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934552/
https://www.ncbi.nlm.nih.gov/pubmed/36798317
http://dx.doi.org/10.1101/2023.02.06.527204

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