Aminobisphosphonates reactivate the latent reservoir in people living with HIV-1

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Antiretroviral therapy (ART) is not curative due to the existence of cellular reservoirs of latent HIV-1 that persist during therapy. Current research efforts to cure HIV-1 infection include “shock and kill” strategies to disrupt latency using small molecules or latency-reversing agents (LRAs) to in...

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Detalles Bibliográficos
Autores principales: Sanz, Marta, Weideman, Ann Marie K., Ward, Adam R., Clohosey, Matthew L., Garcia-Recio, Susana, Selitsky, Sara R., Mann, Brendan T., Iannone, Marie Anne, Whitworth, Chloe P., Chitrakar, Alisha, Garrido, Carolina, Kirchherr, Jennifer, Coffey, Alisha R., Tsai, Yi-Hsuan, Samir, Shahryar, Xu, Yinyan, Copertino, Dennis, Bosque, Alberto, Jones, Brad R., Parker, Joel S., Hudgens, Michael G., Goonetilleke, Nilu, Soriano-Sarabia, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9934553/
https://www.ncbi.nlm.nih.gov/pubmed/36798291
http://dx.doi.org/10.1101/2023.02.07.527421

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